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The annotation and conditions in this rule are derived from the following entries: Q8UZL8 (NSP3_ROTRH)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_04094
    • taxon = Rotavirus
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 150 - 206 aligns to entry Q8UZL8 (individually applies "Dimerization")
    • Subsequence at position 166 - 237 aligns to entry Q8UZL8 (individually applies "")
    • Subsequence at position 170 - 234 aligns to entry Q8UZL8 (individually applies "Interaction with host ZC3H7B")
    • Subsequence at position 208 - @CTER@ aligns to entry Q8UZL8 (individually applies "Interaction with host EIF4G1")
    • Subsequence at position @NTER@ - 149 aligns to entry Q8UZL8 (individually applies "RNA-binding")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Non-structural protein 3
    Short name:
    Alternative name(s):
    Non-structural RNA-binding protein 34
    Short name:

Sequence similaritiesi


  • Plays an important role in stimulating the translation of viral mRNAs. These mRNAs are capped but not polyadenylated, instead terminating in a conserved sequence 'GACC' at the 3' that is recognized by NSP3, which competes with host PABPC1 for EIF4G1 binding. The interaction between NSP3 and host EIF4G1 stabilizes the EIF4E-EIF4G1 interaction, thereby facilitating the initiation of capped mRNA translation.

Subcellular locationi

Subunit structurei

  • Homodimer. Interacts (via the coiled-coil region) with host ZC3H7B (via LD motif). Interacts with host EIF4G1.


  • Dimerization (to residues corresponding to positions 150 - 206)
  • Interaction with host ZC3H7B (to residues corresponding to positions 170 - 234)
  • Interaction with host EIF4G1 (to residues corresponding to positions 208 - @CTER@i)
  • RNA-binding (to residues corresponding to positions @NTER@i - 149)

Coiled coili

  • (to residues corresponding to positions 166 - 237)


GO (Gene Ontology) termsi

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