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If a protein meets these conditions... i

Common conditions

Special conditions

... then these annotations are applied i

Protein namesi

  • Recommended name:
    NADH-quinone oxidoreductase subunit F (EC:1.6.5.11)
  • Recommended name:
    NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)

Functioni

  • NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.
  • Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain.

Subcellular locationi

Catalytic activityi

  • NADH + a quinone = NAD+ + a quinol.
  • NADH + acceptor = NAD+ + reduced acceptor.
  • NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Sequence similaritiesi

Cofactori

Keywordsi

GO (Gene Ontology) termsi

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