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The annotation and conditions in this rule are derived from the following entries: Q9YI37 (SUCB1_COLLI), P0A836 (SUCC_ECOLI), P53590 (SUCB2_PIG)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_03220
    • taxon = Metazoa
    • fragment ≠ the sequence is fragmented
    • Matches HAMAP signature MF_03220
    • taxon = Amoebozoa
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 222 - 222 aligns to "D" in entry Q9YI37 Subsequence at position 208 - 208 aligns to "N" in entry Q9YI37
  • Subsequence at position 222 - 222 aligns to "D" in entry Q9YI37 (applies "Magnesium") Subsequence at position 208 - 208 aligns to "N" in entry Q9YI37 (applies "Magnesium")
    • Subsequence at position 273 - 273 aligns to "N" in entry Q9YI37 (individually applies "Substrate; shared with subunit alpha")
    • Subsequence at position 55 - 57 aligns to "G-R-G" in entry Q9YI37 (individually applies "ATP")
    • Subsequence at position 112 - 112 aligns to "[YF]" in entry Q9YI37 (individually applies "Important for substrate specificity")
    • Subsequence at position 44 - 44 aligns to "[DN]" in entry Q9YI37 (individually applies "Important for substrate specificity")
    • Subsequence at position 48 - 48 aligns to "K" in entry Q9YI37 (individually applies "ATP")
    • Subsequence at position 330 - 332 aligns to "G-I-[VM]" in entry Q9YI37 (individually applies "Substrate binding; shared with subunit alpha")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

  • Recommended name:
    Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC:6.2.1.5)
    Alternative name(s):
    ATP-specific succinyl-CoA synthetase subunit beta
    Short name:
    A-SCS
    Succinyl-CoA synthetase beta-A chain
    Short name:
    SCS-betaA

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:SUCLA2

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

  • Pathwayi: tricarboxylic acid cycle

    This protein is involved in step 1 of the subpathway that synthesizes succinate from succinyl-CoA (ligase route). This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinate from succinyl-CoA (ligase route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi

  • ATP (to residues corresponding to positions 55 - 57)

<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei

  • Important for substrate specificity (to residues corresponding to position 112)
  • Important for substrate specificity (to residues corresponding to position 44)

<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni

  • Substrate binding; shared with subunit alpha (to residues corresponding to positions 330 - 332)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Substrate; shared with subunit alpha (to residues corresponding to position 273)
  • ATP (to residues corresponding to position 48)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Magnesium (to residues corresponding to position 222)
  • Magnesium (to residues corresponding to position 208)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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