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The annotation and conditions in this rule are derived from the following entries: P23395 (SYM_THET8), P9WFU5 (SYM_MYCTU), P23920 (SYM_GEOSE)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01228
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 127 - 127 does not align to "C" in entry P23395
    • Subsequence at position 127 - 127 aligns to "C" in entry P23395
    • Subsequence at position 130 - 130 aligns to "C" in entry P23395
    • Subsequence at position 144 - 144 aligns to "C" in entry P23395
    • Subsequence at position 147 - 147 aligns to "[HC]" in entry P23395
    • Subsequence at position 147 - 147 does not align to "[HC]" in entry P23395
    • Subsequence at position 152 - 152 aligns to "[HC]" in entry Q55729
    • Subsequence at position 127 - 127 aligns to "C" in entry P23395
    • Subsequence at position 300 - 300 aligns to "K" in entry P47267
    • Subsequence at position 147 - 147 aligns to "[HC]" in entry P23395
    • Subsequence at position 130 - 130 aligns to "C" in entry P23395
    • Subsequence at position 144 - 144 aligns to "C" in entry P23395
    • Subsequence at position 297 - 301 aligns to "K-[MI]-[SG]-K-[ST]" in entry P23395 (individually applies "'KMSKS' region")
    • Subsequence at position 12 - 22 aligns to "[YDFAS]-Y-x(5)-H-[LIV]-G-[SHN]" in entry P23395 (individually applies "'HIGH' region")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

  • Recommended name:
    Methionine--tRNA ligase (EC:6.1.1.10)
    Alternative name(s):
    Methionyl-tRNA synthetase
    Short name:
    MetRS

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:metG

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Homodimer.
  • Monomer.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Zinc (to residues corresponding to position 152)
  • Zinc (to residues corresponding to position 127)
  • Zinc (to residues corresponding to position 147)
  • Zinc (to residues corresponding to position 130)
  • Zinc (to residues corresponding to position 144)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • ATP (to residues corresponding to position 300)

<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi

  • 'KMSKS' region (to residues corresponding to positions 297 - 301)
  • 'HIGH' region (to residues corresponding to positions 12 - 22)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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