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The annotation and conditions in this rule are derived from the following entries: P21889 (SYD_ECOLI), P36419 (SYD_THETH), Q5SKD2 (SYD_THET8), P56459 (SYDND_HELPY), Q51422 (SYDND_PSEAE), Q9RUN7 (SYD_DEIRA), O84546 (SYDND_CHLTR)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 31 - 31 aligns to "H" in entry Q51422
    • Subsequence at position 82 - 82 aligns to "G" in entry Q51422
    • Subsequence at position 31 - 31 does not align to "H" in entry Q51422
    • Subsequence at position 82 - 82 does not align to "G" in entry Q51422
    • Subsequence at position 177 - 177 aligns to "E" in entry P36419 (individually applies "Aspartate")
    • Subsequence at position 232 - 232 aligns to "Q" in entry P36419 (individually applies "ATP")
    • Subsequence at position 223 - 223 aligns to "R" in entry P36419 (individually applies "Aspartate")
    • Subsequence at position 476 - 476 aligns to "E" in entry P36419 (individually applies "ATP")
    • Subsequence at position 528 - 531 aligns to "G-x-x-R" in entry P36419 (individually applies "ATP")
    • Subsequence at position 223 - 225 aligns to "R-x-E" in entry P36419 (individually applies "ATP")
    • Subsequence at position 442 - 442 aligns to "H" in entry P36419 (individually applies "Aspartate")
    • Subsequence at position 483 - 483 aligns to "R" in entry P36419 (individually applies "Aspartate")
    • Subsequence at position 201 - 204 aligns to "Q-x-x-K" in entry P36419 (individually applies "Aspartate")
    • Subsequence at position 82 - 82 aligns to "G" in entry Q51422
    • Subsequence at position 31 - 31 aligns to "H" in entry Q51422

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi

  • Recommended name:
    Aspartate--tRNA(Asp/Asn) ligase (EC:6.1.1.23)
    Alternative name(s):
    Non-discriminating aspartyl-tRNA synthetase
    Short name:
    ND-AspRS
    Aspartyl-tRNA synthetase
    Short name:
    AspRS
  • Recommended name:
    Aspartate--tRNA ligase (EC:6.1.1.12)
    Alternative name(s):
    Aspartyl-tRNA synthetase
    Short name:
    AspRS

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:aspS

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Homodimer.

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
  • Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).

<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni

  • Aspartate (to residues corresponding to positions 201 - 204)

<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei

  • Important for tRNA non-discrimination (to residues corresponding to position 82)
  • Important for tRNA non-discrimination (to residues corresponding to position 31)

<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi

  • ATP (to residues corresponding to positions 528 - 531)
  • ATP (to residues corresponding to positions 223 - 225)

<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Aspartate (to residues corresponding to position 177)
  • ATP (to residues corresponding to position 232)
  • Aspartate (to residues corresponding to position 223)
  • ATP (to residues corresponding to position 476)
  • Aspartate (to residues corresponding to position 442)
  • Aspartate (to residues corresponding to position 483)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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