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The annotation and conditions in this rule are derived from the following entries: Q1LCS4 (3HAO_CUPMC), Q83V26 (3HAO_PSEFL)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00825
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 51 - 51 aligns to "H" in entry Q1LCS4 Subsequence at position 95 - 95 aligns to "H" in entry Q1LCS4 Subsequence at position 57 - 57 aligns to "E" in entry Q1LCS4
    • Subsequence at position 162 - 162 aligns to "C" in entry Q1LCS4 Subsequence at position 125 - 125 aligns to "C" in entry Q1LCS4 Subsequence at position 128 - 128 aligns to "C" in entry Q1LCS4 Subsequence at position 165 - 165 aligns to "C" in entry Q1LCS4
    • Subsequence at position 51 - 51 aligns to "H" in entry Q1LCS4 Subsequence at position 95 - 95 aligns to "H" in entry Q1LCS4 Subsequence at position 57 - 57 aligns to "E" in entry Q1LCS4
    • Subsequence at position 162 - 162 aligns to "C" in entry Q1LCS4 Subsequence at position 125 - 125 aligns to "C" in entry Q1LCS4 Subsequence at position 128 - 128 aligns to "C" in entry Q1LCS4 Subsequence at position 165 - 165 aligns to "C" in entry Q1LCS4
    • Subsequence at position 51 - 51 aligns to "H" in entry Q1LCS4 Subsequence at position 95 - 95 aligns to "H" in entry Q1LCS4 Subsequence at position 57 - 57 aligns to "E" in entry Q1LCS4
    • Subsequence at position 162 - 162 does not align to "C" in entry Q1LCS4 Subsequence at position 125 - 125 does not align to "C" in entry Q1LCS4 Subsequence at position 128 - 128 does not align to "C" in entry Q1LCS4 Subsequence at position 165 - 165 does not align to "C" in entry Q1LCS4
    • Subsequence at position 162 - 162 aligns to "C" in entry Q1LCS4 Subsequence at position 125 - 125 aligns to "C" in entry Q1LCS4 Subsequence at position 128 - 128 aligns to "C" in entry Q1LCS4 Subsequence at position 165 - 165 aligns to "C" in entry Q1LCS4
    • Subsequence at position 51 - 51 does not align to "H" in entry Q1LCS4 Subsequence at position 95 - 95 does not align to "H" in entry Q1LCS4 Subsequence at position 57 - 57 does not align to "E" in entry Q1LCS4
  • Subsequence at position 51 - 51 aligns to "H" in entry Q1LCS4 (applies "Iron 1; catalytic") Subsequence at position 95 - 95 aligns to "H" in entry Q1LCS4 (applies "Iron 1; catalytic") Subsequence at position 57 - 57 aligns to "E" in entry Q1LCS4 (applies "Iron 1; catalytic")
  • Subsequence at position 162 - 162 aligns to "C" in entry Q1LCS4 (applies "Iron 2") Subsequence at position 125 - 125 aligns to "C" in entry Q1LCS4 (applies "Iron 2") Subsequence at position 128 - 128 aligns to "C" in entry Q1LCS4 (applies "Iron 2") Subsequence at position 165 - 165 aligns to "C" in entry Q1LCS4 (applies "Iron 2")
    • Subsequence at position 57 - 57 aligns to "E" in entry Q1LCS4 (individually applies "Substrate")
    • Subsequence at position 47 - 47 aligns to "R" in entry Q1LCS4 (individually applies "Dioxygen")
    • Subsequence at position 99 - 99 aligns to "R" in entry Q1LCS4 (individually applies "Substrate")
    • Subsequence at position 110 - 110 aligns to "E" in entry Q1LCS4 (individually applies "Substrate")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

  • Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenase (EC:1.13.11.6)
    Alternative name(s):
    3-hydroxyanthranilate oxygenase
    Short name:
    3-HAO
    3-hydroxyanthranilic acid dioxygenase
    Short name:
    HAD

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:nbaC

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Homodimer.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

  • Pathwayi: NAD(+) biosynthesis

    This protein is involved in step 3 of the subpathway that synthesizes quinolinate from L-kynurenine. This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Substrate (to residues corresponding to position 57)
  • Dioxygen (to residues corresponding to position 47)
  • Substrate (to residues corresponding to position 99)
  • Substrate (to residues corresponding to position 110)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Iron 1; catalytic (to residues corresponding to position 51)
  • Iron 1; catalytic (to residues corresponding to position 95)
  • Iron 1; catalytic (to residues corresponding to position 57)
  • Iron 2 (to residues corresponding to position 162)
  • Iron 2 (to residues corresponding to position 125)
  • Iron 2 (to residues corresponding to position 128)
  • Iron 2 (to residues corresponding to position 165)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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