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The annotation and conditions in this rule are derived from the following entries: P04295 (TRM3_HHV11)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 357 - 357 aligns to "E" in entry P04295 (individually applies "For ATPase activity")
    • Subsequence at position 707 - 707 aligns to "D" in entry P04295 (individually applies "For nuclease activity")
    • Subsequence at position 581 - 581 aligns to "E" in entry P04295 (individually applies "For nuclease activity")
    • Subsequence at position 352 - 357 aligns to "[LI]-L-[FYLI]-V-D-E" in entry P04295 (individually applies "Walker B motif")
    • Subsequence at position 509 - 509 aligns to "D" in entry P04295 (individually applies "For nuclease activity")
    • Subsequence at position 258 - 265 aligns to "[VI]-P-R-R-H-G-K-T" in entry P04295 (individually applies "Walker A motif")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:TRM3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    • Host nucleus
    • Note: Responsible for the nuclear localization of the two others subunits TRM1 and TRM2.

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Interacts with the terminase subunits TRM1 and TRM2. Interacts with portal protein.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.

<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi

  • Walker B motif (to residues corresponding to positions 352 - 357)
  • Walker A motif (to residues corresponding to positions 258 - 265)
  • Nuclear localization signal (to residues corresponding to positions 183 - 189)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • For ATPase activity (to residues corresponding to position 357)
  • For nuclease activity (to residues corresponding to position 707)
  • For nuclease activity (to residues corresponding to position 581)
  • For nuclease activity (to residues corresponding to position 509)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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