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The annotation and conditions in this rule are derived from the following entries: P00388 (NCPR_RAT), P16435 (NCPR_HUMAN), P16603 (NCPR_YEAST)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_03212
    • taxon = Eukaryota
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 86 - 91 aligns to "[ST]-Q-T-G-T-[AG]" in entry P00388 (individually applies "FMN")
    • Subsequence at position 138 - 141 aligns to "[AS]-T-Y-G" in entry P00388 (individually applies "FMN")
    • Subsequence at position 173 - 182 aligns to "L-G-[ND]-x-[TQ]-Y-E-x-[FY]-[NQ]" in entry P00388 (individually applies "FMN")
    • Subsequence at position 208 - 208 aligns to "D" in entry P00388 (individually applies "FMN")
    • Subsequence at position 298 - 298 aligns to "R" in entry P00388 (individually applies "NADP")
    • Subsequence at position 424 - 424 aligns to "R" in entry P00388 (individually applies "FAD")
    • Subsequence at position 454 - 457 aligns to "R-[YF]-Y-S" in entry P00388 (individually applies "FAD")
    • Subsequence at position 472 - 474 aligns to "[CT]-x-[AVI]" in entry P00388 (individually applies "FAD")
    • Subsequence at position 478 - 478 aligns to "Y" in entry P00388 (individually applies "FAD")
    • Subsequence at position 488 - 491 aligns to "G-[VL]-x-[ST]" in entry P00388 (individually applies "FAD")
    • Subsequence at position 535 - 535 aligns to "T" in entry P00388 (individually applies "NADP")
    • Subsequence at position 596 - 597 aligns to "S-R" in entry P00388 (individually applies "NADP")
    • Subsequence at position 602 - 606 aligns to "K-x-Y-V-[QT]" in entry P00388 (individually applies "NADP")
    • Subsequence at position 639 - 639 aligns to "[DE]" in entry P00388 (individually applies "NADP")
    • Subsequence at position 677 - 677 aligns to "W" in entry P00388 (individually applies "FAD")
    • Predicted transmembrane

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

  • Recommended name:
    NADPH--cytochrome P450 reductase (EC:1.6.2.4)
    Short name:
    CPR
    Short name:
    P450R

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi

  • Name:POR
  • Name:cprA
  • Name:NCP1

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This section describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.
  • This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei

  • Helical (to residues corresponding to positions @FROM@i - @TO@i)

<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi

  • FMN (to residues corresponding to positions 86 - 91)
  • FMN (to residues corresponding to positions 138 - 141)
  • FMN (to residues corresponding to positions 173 - 182)
  • FAD (to residues corresponding to positions 454 - 457)
  • FAD (to residues corresponding to positions 472 - 474)
  • FAD (to residues corresponding to positions 488 - 491)
  • NADP (to residues corresponding to positions 596 - 597)
  • NADP (to residues corresponding to positions 602 - 606)

<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • FMN (to residues corresponding to position 208)
  • NADP (to residues corresponding to position 298)
  • FAD (to residues corresponding to position 424)
  • FAD (to residues corresponding to position 478)
  • NADP (to residues corresponding to position 535)
  • NADP (to residues corresponding to position 639)
  • FAD (to residues corresponding to position 677)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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