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The annotation and conditions in this rule are derived from the following entries: P00579 (RPOD_ECOLI), P0A0J0 (SIGA_STAA8), P77994 (SIGA_THEMA), Q72L95 (SIGA_THET2), Q9EZJ8 (SIGA_THEAQ)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00963
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 547 - 600 aligns to entry P00579 (individually applies "Sigma-70 factor domain-4")
    • Subsequence at position 379 - 449 aligns to entry P00579 (individually applies "Sigma-70 factor domain-2")
    • Subsequence at position 403 - 406 aligns to "D-[LI]-[IVLF]-[QE]" in entry P00579 (individually applies "Interaction with polymerase core subunit RpoC")
    • Subsequence at position 458 - 534 aligns to entry P00579 (individually applies "Sigma-70 factor domain-3")
    • Subsequence at position 573 - 592 aligns to entry P00579 (individually applies "H-T-H motif")

... then these annotations are applied i

<p>This subsection of the <a href="">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi

  • Recommended name:
    RNA polymerase sigma factor RpoD
    Alternative name(s):
  • Recommended name:
    RNA polymerase sigma factor SigA

<p>This subsection of the <a href="">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi

  • Name:rpoD
  • Name:sigA

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the <a href="">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Interacts transiently with the RNA polymerase catalytic core.

<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni

  • Sigma-70 factor domain-4 (to residues corresponding to positions 547 - 600)
  • Sigma-70 factor domain-2 (to residues corresponding to positions 379 - 449)
  • Sigma-70 factor domain-3 (to residues corresponding to positions 458 - 534)

<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi

  • Interaction with polymerase core subunit RpoC (to residues corresponding to positions 403 - 406)

<p>This subsection of the <a href="">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi

  • H-T-H motif (to residues corresponding to positions 573 - 592)

<p>UniProtKB Keywords constitute a <a href="">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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