UniRule: UR000184474
Source Rule HAMAP: MF_00966
The annotation and conditions in this rule are derived from the following entries: P11411 (G6PD_LEUME), P0AC53 (G6PD_ECOLI), O68282 (G6PD_PSEAE), Q5FUK8 (G6PD_GLUOX)
If a protein meets these conditions... i
Common conditions
Special conditions
- Subsequence at position 241 - 241 aligns to "H" in entry P11411 (individually applies "Proton acceptor")
- Subsequence at position 183 - 183 aligns to "K" in entry P11411 (individually applies "Substrate")
- Subsequence at position 149 - 149 aligns to "K" in entry P11411 (individually applies "NADP")
- Subsequence at position 13 - 20 aligns to "G-[GAS]-[TS]-G-[DEN]-L-[AST]-[KR]" in entry P11411 (individually applies "NADP")
- Subsequence at position 344 - 344 aligns to "K" in entry P11411 (individually applies "Substrate")
- Subsequence at position 236 - 236 aligns to "D" in entry P11411 (individually applies "Substrate")
- Subsequence at position 179 - 179 aligns to "H" in entry P11411 (individually applies "Substrate")
- Subsequence at position 47 - 47 aligns to "[RAS]" in entry P11411 (individually applies "NADP")
- Subsequence at position 339 - 339 aligns to "K" in entry P11411 (individually applies "Substrate")
- Subsequence at position 217 - 217 aligns to "E" in entry P11411 (individually applies "Substrate")
- Subsequence at position 86 - 87 aligns to "[DE]-[VLIF]" in entry P11411 (individually applies "NADP")
... then these annotations are applied i
Protein namei
- Recommended name:Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)Short name:G6PD
Gene namei
- Name:zwf
Pathwayi
Pathwayi: pentose phosphate pathway
This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage). This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.
Catalytic activityi
Sequence similaritiesi
- Belongs to the glucose-6-phosphate dehydrogenase family.
Functioni
- Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
Nucleotide bindingi
- NADP (to residues corresponding to positions 13 - 20)
- NADP (to residues corresponding to positions 86 - 87)
Active sitei
- Proton acceptor (to residues corresponding to position 241)
Binding sitei
- Substrate (to residues corresponding to position 183)
- NADP (to residues corresponding to position 149)
- Substrate (to residues corresponding to position 344)
- Substrate (to residues corresponding to position 236)
- Substrate (to residues corresponding to position 179)
- NADP (to residues corresponding to position 47)
- Substrate (to residues corresponding to position 339)
- Substrate (to residues corresponding to position 217)
Keywordsi
GO (Gene Ontology) termsi
- GO:0004345 glucose-6-phosphate dehydrogenase activity
- GO:0006098 pentose-phosphate shunt
- GO:0050661 NADP binding