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UniRule: UR000184474

Source Rule HAMAP: MF_00966

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The annotation and conditions in this rule are derived from the following entries: P11411 (G6PD_LEUME), P0AC53 (G6PD_ECOLI), O68282 (G6PD_PSEAE), Q5FUK8 (G6PD_GLUOX)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00966
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 241 - 241 aligns to "H" in entry P11411 (individually applies "Proton acceptor")
    • Subsequence at position 183 - 183 aligns to "K" in entry P11411 (individually applies "Substrate")
    • Subsequence at position 149 - 149 aligns to "K" in entry P11411 (individually applies "NADP")
    • Subsequence at position 13 - 20 aligns to "G-[GAS]-[TS]-G-[DEN]-L-[AST]-[KR]" in entry P11411 (individually applies "NADP")
    • Subsequence at position 344 - 344 aligns to "K" in entry P11411 (individually applies "Substrate")
    • Subsequence at position 236 - 236 aligns to "D" in entry P11411 (individually applies "Substrate")
    • Subsequence at position 179 - 179 aligns to "H" in entry P11411 (individually applies "Substrate")
    • Subsequence at position 47 - 47 aligns to "[RAS]" in entry P11411 (individually applies "NADP")
    • Subsequence at position 339 - 339 aligns to "K" in entry P11411 (individually applies "Substrate")
    • Subsequence at position 217 - 217 aligns to "E" in entry P11411 (individually applies "Substrate")
    • Subsequence at position 86 - 87 aligns to "[DE]-[VLIF]" in entry P11411 (individually applies "NADP")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:zwf

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi

  • NADP (to residues corresponding to positions 13 - 20)
  • NADP (to residues corresponding to positions 86 - 87)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Proton acceptor (to residues corresponding to position 241)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Substrate (to residues corresponding to position 183)
  • NADP (to residues corresponding to position 149)
  • Substrate (to residues corresponding to position 344)
  • Substrate (to residues corresponding to position 236)
  • Substrate (to residues corresponding to position 179)
  • NADP (to residues corresponding to position 47)
  • Substrate (to residues corresponding to position 339)
  • Substrate (to residues corresponding to position 217)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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