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The annotation and conditions in this rule are derived from the following entries: P0AG18 (PURE_ECOLI)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 16 - 16 aligns to "S" in entry P0AG18 (individually applies "Substrate")
    • Subsequence at position 19 - 19 aligns to "D" in entry P0AG18 (individually applies "Substrate")
    • Subsequence at position 46 - 46 aligns to "R" in entry P0AG18 (individually applies "Substrate")

... then these annotations are applied i

Protein namei

  • Recommended name:
    N5-carboxyaminoimidazole ribonucleotide mutase (EC:5.4.99.18)
    Short name:
    N5-CAIR mutase
    Alternative name(s):
    5-(carboxyamino)imidazole ribonucleotide mutase

Gene namei

  • Name:purE

Pathwayi

Functioni

  • Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

Catalytic activityi

  • 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.

Sequence similaritiesi

Binding sitei

  • Substrate (to residues corresponding to position 16)
  • Substrate (to residues corresponding to position 19)
  • Substrate (to residues corresponding to position 46)

Keywordsi

GO (Gene Ontology) termsi

  • GO:0006189 'de novo' IMP biosynthetic process
  • GO:0034023 5-(carboxyamino)imidazole ribonucleotide mutase activity
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