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The annotation and conditions in this rule are derived from the following entries: O67883 (THIL_AQUAE), P55881 (THIL_SALTY), P0AGG0 (THIL_ECOLI), A3MTW6 (THIL_PYRCJ)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 142 - 142 aligns to "[RK]" in entry O67883 (individually applies "ATP")
    • Subsequence at position 209 - 209 aligns to "[ST]" in entry O67883 (individually applies "ATP")
    • Subsequence at position 43 - 43 aligns to "D" in entry O67883 (individually applies "Magnesium 2")
    • Subsequence at position 27 - 27 aligns to "[DE]" in entry O67883 (individually applies "Magnesium 4; via carbonyl oxygen")
    • Subsequence at position 43 - 43 aligns to "D" in entry O67883 (individually applies "Magnesium 1")
    • Subsequence at position 42 - 42 aligns to "[TS]" in entry O67883 (individually applies "Magnesium 1; via carbonyl oxygen")
    • Subsequence at position 210 - 210 aligns to "D" in entry O67883 (individually applies "Magnesium 5")
    • Subsequence at position 41 - 41 aligns to "[TS]" in entry O67883 (individually applies "Magnesium 4")
    • Subsequence at position 260 - 260 aligns to "[ED]" in entry O67883 (individually applies "Substrate")
    • Subsequence at position 303 - 303 aligns to "[WYF]" in entry O67883 (individually applies "Substrate")
    • Subsequence at position 119 - 119 aligns to "[ND]" in entry O67883 (individually applies "Magnesium 1")
    • Subsequence at position 50 - 50 aligns to "[HD]" in entry O67883 (individually applies "Substrate")
    • Subsequence at position 207 - 207 aligns to "D" in entry O67883 (individually applies "Magnesium 3")
    • Subsequence at position 27 - 27 aligns to "[DE]" in entry O67883 (individually applies "Magnesium 3")
    • Subsequence at position 101 - 101 aligns to "Y" in entry O67883 (individually applies "ATP")
    • Subsequence at position 118 - 119 aligns to "G-[ND]" in entry O67883 (individually applies "ATP")
    • Subsequence at position 71 - 71 aligns to "D" in entry O67883 (individually applies "Magnesium 2")
    • Subsequence at position 71 - 71 aligns to "D" in entry O67883 (individually applies "Magnesium 3")
    • Subsequence at position 71 - 71 aligns to "D" in entry O67883 (individually applies "Magnesium 4")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:thiL

<p>This subsection of the 'Function' section describes relevant information that doesn't fall into the scope of any other subsections, but is thought to be valuable enough to be cited in UniProtKB.<p><a href='/help/miscellaneous' target='_top'>More...</a></p>Miscellaneousi

  • Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

  • Pathwayi: thiamine diphosphate biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes thiamine diphosphate from thiamine phosphate. This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes thiamine diphosphate from thiamine phosphate, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • ATP (to residues corresponding to position 142)
  • ATP (to residues corresponding to position 209)
  • Substrate (to residues corresponding to position 260)
  • Substrate (to residues corresponding to position 303)
  • Substrate (to residues corresponding to position 50)
  • ATP (to residues corresponding to position 101)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi

  • ATP (to residues corresponding to positions 118 - 119)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Magnesium 2 (to residues corresponding to position 43)
  • Magnesium 4; via carbonyl oxygen (to residues corresponding to position 27)
  • Magnesium 1 (to residues corresponding to position 43)
  • Magnesium 1; via carbonyl oxygen (to residues corresponding to position 42)
  • Magnesium 5 (to residues corresponding to position 210)
  • Magnesium 4 (to residues corresponding to position 41)
  • Magnesium 1 (to residues corresponding to position 119)
  • Magnesium 3 (to residues corresponding to position 207)
  • Magnesium 3 (to residues corresponding to position 27)
  • Magnesium 2 (to residues corresponding to position 71)
  • Magnesium 3 (to residues corresponding to position 71)
  • Magnesium 4 (to residues corresponding to position 71)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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