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If a protein meets these conditions... i

Common conditions

... then these annotations are applied i

Protein namei

  • Recommended name:
    Pyruvate formate-lyase-activating enzyme (EC:1.97.1.4)

Cofactori

  • [4Fe-4S] clusterNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Subcellular locationi

Functioni

  • Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.

Sequence similaritiesi

Catalytic activityi

  • S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical.

Keywordsi

GO (Gene Ontology) termsi

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