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The annotation and conditions in this rule are derived from the following entries: Q08048 (HGF_MOUSE), P26927 (HGFL_HUMAN), P14210 (HGF_HUMAN)

If a protein meets these conditions... i

Common conditions

    • Matches PIR Superfamily signature PIRSF001152
    • sequence length = 449 - 730
    • taxon = Eukaryota
    • fragment ≠ the sequence is fragmented

Special conditions

... then these annotations are applied i

Protein namei

  • Recommended name:
    Hepatocyte growth factor
    Alternative name(s):
    Hepatopoietin-A
    Scatter factor

Functioni

  • Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

Sequence similaritiesi

Subunit structurei

  • Dimer of an alpha chain and a beta chain linked by a disulfide bond.

Keywordsi

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Main funding by: National Institutes of Health

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