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The annotation and conditions in this rule are derived from the following entries: P15700 (KCY_YEAST), P20425 (KCY_DICDI), P30085 (KCY_HUMAN)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_03172
    • taxon = Eukaryota
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 26 - 31 aligns to "G-x-G-K-G-T" in entry P15700 (individually applies "ATP")
    • Subsequence at position 187 - 187 aligns to entry P15700 (individually applies "ATP; via carbonyl oxygen")
    • Subsequence at position 104 - 107 aligns to "G-[FY]-P-R" in entry P15700 (individually applies "NMP")
    • Subsequence at position 74 - 76 aligns to "x-[IL]-[VL]" in entry P15700 (individually applies "NMP")
    • Subsequence at position 46 - 76 aligns to entry P15700 (individually applies "NMPbind")
    • Subsequence at position 141 - 151 aligns to entry P15700 (individually applies "LID")
    • Subsequence at position 159 - 159 aligns to "R" in entry P15700 (individually applies "NMP")
    • Subsequence at position 52 - 52 aligns to "R" in entry P15700 (individually applies "NMP")
    • Subsequence at position 142 - 142 aligns to "R" in entry P15700 (individually applies "ATP")
    • Subsequence at position 148 - 148 aligns to "R" in entry P15700 (individually applies "NMP")
    • taxon = Fungi
    • Subsequence at position 111 - 111 aligns to "Q" in entry P15700
    • taxon ≠ Fungi
    • Subsequence at position 98 - 98 aligns to "N" in entry P20425

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi

  • Recommended name:
    Uridylate kinase (EC:2.7.4.14)
    Short name:
    UK
    Alternative name(s):
    ATP:UMP phosphotransferase
    Deoxycytidylate kinase
    Short name:
    CK
    Short name:
    dCMP kinase
    Uridine monophosphate kinase
    Short name:
    UMP kinase
    Short name:
    UMPK
  • Recommended name:
    UMP-CMP kinase (EC:2.7.4.14)
    Alternative name(s):
    Deoxycytidylate kinase
    Short name:
    CK
    Short name:
    dCMP kinase
    Nucleoside-diphosphate kinase (EC:2.7.4.6)
    Uridine monophosphate/cytidine monophosphate kinase
    Short name:
    UMP/CMP kinase
    Short name:
    UMP/CMPK
  • Recommended name:
    UMP-CMP kinase (EC:2.7.4.14)
    Alternative name(s):
    Deoxycytidylate kinase
    Short name:
    CK
    Short name:
    dCMP kinase
    Uridine monophosphate/cytidine monophosphate kinase
    Short name:
    UMP/CMP kinase
    Short name:
    UMP/CMPK

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi

  • Name:CMPK1, Synonym:CMPK
  • Name:pyrK
  • Name:URA6

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

  • Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.
  • Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
  • Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Monomer.

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi

  • ATP (to residues corresponding to positions 26 - 31)
  • NMP (to residues corresponding to positions 104 - 107)
  • NMP (to residues corresponding to positions 74 - 76)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • ATP; via carbonyl oxygen (to residues corresponding to position 187)
  • NMP (to residues corresponding to position 159)
  • NMP (to residues corresponding to position 52)
  • ATP (to residues corresponding to position 142)
  • NMP (to residues corresponding to position 148)
  • NMP (to residues corresponding to position 111)
  • CMP (to residues corresponding to position 98)

<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni

  • NMPbind (to residues corresponding to positions 46 - 76)
  • LID (to residues corresponding to positions 141 - 151)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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