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The annotation and conditions in this rule are derived from the following entries: P60228 (EIF3E_HUMAN), P60229 (EIF3E_MOUSE), O94513 (EIF3E_SCHPO), Q6DRI1 (EI3EA_DANRE)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_03004
    • taxon = Eukaryota
    • fragment ≠ the sequence is fragmented

Special conditions

... then these annotations are applied i

Protein namesi

  • Recommended name:
    Eukaryotic translation initiation factor 3 subunit E
    Short name:
    eIF3e
  • Recommended name:
    Eukaryotic translation initiation factor 3 subunit E
    Short name:
    eIF3e
    Alternative name(s):
    Eukaryotic translation initiation factor 3 subunit 6
    eIF-3 p48
  • Recommended name:
    Eukaryotic translation initiation factor 3 subunit E
    Short name:
    eIF3e
    Alternative name(s):
    Eukaryotic translation initiation factor 3 subunit 6

Gene namesi

  • Name:INT6
  • Name:EIF3E, Synonym:EIF3S6, Synonym:INT6
  • Name:eIF3e, Synonym:Int6, Synonym:eIF3-S6
  • Name:eif-3.E
  • Name:EIF3E, Synonym:EIF3S6

Subunit structurei

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.
  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.

Functioni

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

Post-translational modificationi

  • Phosphorylated upon DNA damage, probably by ATM or ATR.

Sequence similaritiesi

Subcellular locationi

Regioni

  • Sufficient for interaction with EPAS1 (to residues corresponding to positions 4 - 128)
  • Sufficient for interaction with TRIM27 (to residues corresponding to positions 9 - 195)
  • Sufficient for interaction with MCM7 (to residues corresponding to positions 351 - 445)

Initiator methioninei

  • Removed (to residues corresponding to position 1)

Modified residuei

  • N-acetylalanine (to residues corresponding to position 2)

Keywordsi

GO (Gene Ontology) termsi

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