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The annotation and conditions in this rule are derived from the following entries: Q99613 (EIF3C_HUMAN), Q8R1B4 (EIF3C_MOUSE), Q6PFQ2 (EIF3C_DANRE), A1ZAX1 (EIF3C_DROME), O14164 (EIF3C_SCHPO), P32497 (EIF3C_YEAST)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_03002
    • taxon = Eukaryota
    • fragment ≠ the sequence is fragmented

Special conditions

    • taxon = Mammalia
    • Subsequence at position 9 - 9 aligns to "S" in entry Q99613 (individually applies "Phosphoserine")
    • Subsequence at position 909 - 909 aligns to "S" in entry Q99613 (individually applies "Phosphoserine")
    • Subsequence at position 13 - 13 aligns to "S" in entry Q99613 (individually applies "Phosphoserine")
    • Subsequence at position 18 - 18 aligns to "S" in entry Q99613 (individually applies "Phosphoserine")
    • Subsequence at position 11 - 11 aligns to "S" in entry Q99613 (individually applies "Phosphoserine")
    • Subsequence at position 16 - 16 aligns to "S" in entry Q99613 (individually applies "Phosphoserine")
    • Subsequence at position 166 - 166 aligns to "S" in entry Q99613 (individually applies "Phosphoserine")
    • Subsequence at position 15 - 15 aligns to "S" in entry Q99613 (individually applies "Phosphoserine")
    • Subsequence at position 39 - 39 aligns to "S" in entry Q99613 (individually applies "Phosphoserine")
    • Subsequence at position 524 - 524 aligns to "T" in entry Q99613 (individually applies "Phosphothreonine")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi

  • Recommended name:
    Eukaryotic translation initiation factor 3 subunit C
    Short name:
    eIF3c
    Alternative name(s):
    Eukaryotic translation initiation factor 3 93 kDa subunit homolog
    Short name:
    eIF3 p93
    Translation initiation factor eIF3, p93 subunit homolog
  • Recommended name:
    Eukaryotic translation initiation factor 3 subunit C
    Short name:
    eIF3c
    Alternative name(s):
    Eukaryotic translation initiation factor 3 subunit 8
    eIF3 p110
  • Recommended name:
    Eukaryotic translation initiation factor 3 subunit C
    Short name:
    eIF3c
    Alternative name(s):
    Eukaryotic translation initiation factor 3 subunit 8

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi

  • Name:NIP1
  • Name:EIF3C, Synonym:EIF3S8
  • Name:eIF3c, Synonym:eIF3-S8
  • Name:eif-3.C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei

  • Phosphoserine (to residues corresponding to position 9)
  • Phosphoserine (to residues corresponding to position 909)
  • Phosphoserine (to residues corresponding to position 13)
  • Phosphoserine (to residues corresponding to position 18)
  • Phosphoserine (to residues corresponding to position 11)
  • Phosphoserine (to residues corresponding to position 16)
  • Phosphoserine (to residues corresponding to position 166)
  • Phosphoserine (to residues corresponding to position 15)
  • Phosphoserine (to residues corresponding to position 39)
  • Phosphothreonine (to residues corresponding to position 524)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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