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The annotation and conditions in this rule are derived from the following entries: P06612 (TOP1_ECOLI), P9WG49 (TOP1_MYCTU)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 168 - 168 aligns to "R" in entry P06612 (individually applies "Interaction with DNA")
    • Subsequence at position 172 - 172 aligns to "D" in entry P06612 (individually applies "Interaction with DNA")
    • Subsequence at position 33 - 33 aligns to "H" in entry P06612 (individually applies "Interaction with DNA")
    • Subsequence at position 321 - 321 aligns to "R" in entry P06612 (individually applies "Interaction with DNA")
    • Subsequence at position 169 - 169 aligns to "R" in entry P06612 (individually applies "Interaction with DNA")
    • Subsequence at position 192 - 197 aligns to "S-x-G-R-V-Q" in entry P06612 (individually applies "Interaction with DNA")
    • Subsequence at position 319 - 319 aligns to "Y" in entry P06612 (individually applies "O-(5'-phospho-DNA)-tyrosine intermediate")
    • Subsequence at position 507 - 507 aligns to "R" in entry P06612 (individually applies "Interaction with DNA")
    • Subsequence at position 184 - 184 aligns to "W" in entry P06612 (individually applies "Interaction with DNA")
    • Subsequence at position 177 - 177 aligns to "Y" in entry P06612 (individually applies "Interaction with DNA")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:topA

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

    • ATP-independent breakage of single-stranded DNA, followed by passage and rejoining. EC:5.6.2.1

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Monomer.

<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei

  • Interaction with DNA (to residues corresponding to position 168)
  • Interaction with DNA (to residues corresponding to position 172)
  • Interaction with DNA (to residues corresponding to position 33)
  • Interaction with DNA (to residues corresponding to position 321)
  • Interaction with DNA (to residues corresponding to position 169)
  • Interaction with DNA (to residues corresponding to position 507)
  • Interaction with DNA (to residues corresponding to position 184)
  • Interaction with DNA (to residues corresponding to position 177)

<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni

  • Interaction with DNA (to residues corresponding to positions 192 - 197)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • O-(5'-phospho-DNA)-tyrosine intermediate (to residues corresponding to position 319)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

  • GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
  • GO:0006265 DNA topological change
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