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The annotation and conditions in this rule are derived from the following entries: P0AB83 (END3_ECOLI), P9WQ11 (END3_MYCTU)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 187 - 187 aligns to "C" in entry P0AB83 Subsequence at position 194 - 194 aligns to "C" in entry P0AB83 Subsequence at position 197 - 197 aligns to "C" in entry P0AB83 Subsequence at position 203 - 203 aligns to "C" in entry P0AB83
  • Subsequence at position 187 - 187 aligns to "C" in entry P0AB83 (applies "Iron-sulfur (4Fe-4S)") Subsequence at position 194 - 194 aligns to "C" in entry P0AB83 (applies "Iron-sulfur (4Fe-4S)") Subsequence at position 197 - 197 aligns to "C" in entry P0AB83 (applies "Iron-sulfur (4Fe-4S)") Subsequence at position 203 - 203 aligns to "C" in entry P0AB83 (applies "Iron-sulfur (4Fe-4S)")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Endonuclease III (EC:4.2.99.18)
    Alternative name(s):
    DNA-(apurinic or apyrimidinic site) lyase

Gene namei

  • Name:nth

Functioni

  • DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Cofactori

Catalytic activityi

  • The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Sequence similaritiesi

Metal bindingi

  • Iron-sulfur (4Fe-4S) (to residues corresponding to position 187)
  • Iron-sulfur (4Fe-4S) (to residues corresponding to position 194)
  • Iron-sulfur (4Fe-4S) (to residues corresponding to position 197)
  • Iron-sulfur (4Fe-4S) (to residues corresponding to position 203)

Keywordsi

GO (Gene Ontology) termsi

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