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The annotation and conditions in this rule are derived from the following entries: Q25QU7 (MDH_FLAFR), P80040 (MDH_CHLAA), P80039 (MDH_CHLTE), P61889 (MDH_ECOLI)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00487
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented
    • Does not match HAMAP signature MF_00488

Special conditions

    • Subsequence at position 33 - 33 aligns to "D" in entry P80040 (individually applies "NAD")
    • Subsequence at position 151 - 151 aligns to "R" in entry P80040 (individually applies "Substrate")
    • Subsequence at position 175 - 175 aligns to "H" in entry P80040 (individually applies "Proton acceptor")
    • Subsequence at position 9 - 14 aligns to "G-x(1,2)-G-x-x-G" in entry P80040 (individually applies "NAD")
    • Subsequence at position 120 - 120 aligns to "N" in entry P80040 (individually applies "Substrate")
    • Subsequence at position 82 - 82 aligns to "R" in entry P80040 (individually applies "Substrate")
    • Subsequence at position 95 - 95 aligns to "N" in entry P80040 (individually applies "NAD")
    • Subsequence at position 118 - 120 aligns to "[VILT]-[GSNAT]-N" in entry P80040 (individually applies "NAD")
    • Subsequence at position 88 - 88 aligns to "R" in entry P80040 (individually applies "Substrate")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:mdh

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the reversible oxidation of malate to oxaloacetate.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • NAD (to residues corresponding to position 33)
  • Substrate (to residues corresponding to position 151)
  • Substrate (to residues corresponding to position 120)
  • Substrate (to residues corresponding to position 82)
  • NAD (to residues corresponding to position 95)
  • Substrate (to residues corresponding to position 88)

<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei

  • Phosphoserine (to residues corresponding to position 149)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi

  • NAD (to residues corresponding to positions 9 - 14)
  • NAD (to residues corresponding to positions 118 - 120)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Proton acceptor (to residues corresponding to position 175)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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