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The annotation and conditions in this rule are derived from the following entries: P0CW93 (LDH2_BIFLO), P00344 (LDH_GEOSE), P00343 (LDH_LACCA), O32765 (LDH_LACHE), P16115 (LDH_THEMA)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00488
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 172 - 172 aligns to "H" in entry P00344 Subsequence at position 157 - 157 aligns to "[RK]" in entry P00344
    • Subsequence at position 223 - 223 aligns to "Y" in entry P13714
    • scientific organism = Staphylococcus aureus
    • Subsequence at position 92 - 92 aligns to "R" in entry P00344 (individually applies "Substrate")
    • Subsequence at position 17 - 17 aligns to "V" in entry P00344 (individually applies "NAD; via amide nitrogen")
    • Subsequence at position 105 - 105 aligns to "[ST]" in entry P00344 (individually applies "NAD")
    • Subsequence at position 233 - 233 aligns to "T" in entry P00344 (individually applies "Substrate")
    • Subsequence at position 69 - 69 aligns to "Y" in entry P00344 (individually applies "NAD")
    • Subsequence at position 179 - 179 aligns to "H" in entry P00344 (individually applies "Proton acceptor")
    • Subsequence at position 124 - 127 aligns to "N-x-x-D" in entry P00344 (individually applies "Substrate binding")
    • Subsequence at position 147 - 147 aligns to "[ST]" in entry P00344 (individually applies "NAD")
    • Subsequence at position 152 - 155 aligns to "D-x-x-R" in entry P00344 (individually applies "Substrate binding")
    • Subsequence at position 38 - 38 aligns to "[DNE]" in entry P00344 (individually applies "NAD")
    • Subsequence at position 43 - 43 aligns to "[RK]" in entry P00344 (individually applies "NAD")
    • Subsequence at position 83 - 84 aligns to "G-[AVL]" in entry P00344 (individually applies "NAD")
    • Subsequence at position 86 - 86 aligns to "Q" in entry P00344 (individually applies "Substrate")
    • Subsequence at position 122 - 124 aligns to "[AIV]-x-N" in entry P00344 (individually applies "NAD")
  • Subsequence at position 172 - 172 aligns to "H" in entry P00344 (applies "Allosteric activator") Subsequence at position 157 - 157 aligns to "[RK]" in entry P00344 (applies "Allosteric activator")
    • Subsequence at position 223 - 223 aligns to "Y" in entry P13714

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:ldh

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the conversion of lactate to pyruvate.

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

  • Allosterically activated by fructose 1,6-bisphosphate (FBP).

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Homotetramer.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

  • Pathwayi: pyruvate fermentation to lactate

    This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate. This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Substrate (to residues corresponding to position 92)
  • NAD; via amide nitrogen (to residues corresponding to position 17)
  • NAD (to residues corresponding to position 105)
  • Substrate (to residues corresponding to position 233)
  • NAD (to residues corresponding to position 69)
  • NAD (to residues corresponding to position 147)
  • NAD (to residues corresponding to position 38)
  • NAD (to residues corresponding to position 43)
  • Substrate (to residues corresponding to position 86)
  • Allosteric activator (to residues corresponding to position 172)
  • Allosteric activator (to residues corresponding to position 157)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi

  • NAD (to residues corresponding to positions 83 - 84)
  • NAD (to residues corresponding to positions 122 - 124)

<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni

  • Substrate binding (to residues corresponding to positions 124 - 127)
  • Substrate binding (to residues corresponding to positions 152 - 155)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Proton acceptor (to residues corresponding to position 179)

<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei

  • Phosphotyrosine (to residues corresponding to position 223)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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