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The annotation and conditions in this rule are derived from the following entries: P23522 (GARL_ECOLI)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 153 - 153 aligns to "E" in entry P23522 Subsequence at position 179 - 179 aligns to "D" in entry P23522
  • Subsequence at position 153 - 153 aligns to "E" in entry P23522 (applies "Magnesium") Subsequence at position 179 - 179 aligns to "D" in entry P23522 (applies "Magnesium")
    • Subsequence at position 179 - 179 aligns to "D" in entry P23522 (individually applies "Substrate")
    • Subsequence at position 89 - 89 aligns to "D" in entry P23522 (individually applies "Increases basicity of active site His")
    • Subsequence at position 75 - 75 aligns to "R" in entry P23522 (individually applies "Transition state stabilizer")
    • Subsequence at position 151 - 151 aligns to "Q" in entry P23522 (individually applies "Substrate")
    • Subsequence at position 178 - 178 aligns to "S" in entry P23522 (individually applies "Substrate; via amide nitrogen")
    • Subsequence at position 50 - 50 aligns to "H" in entry P23522 (individually applies "Proton acceptor")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

  • Recommended name:
    5-keto-4-deoxy-D-glucarate aldolase (EC:4.1.2.20)
    Short name:
    KDGluc aldolase
    Short name:
    KDGlucA
    Alternative name(s):
    2-dehydro-3-deoxy-D-glucarate aldolase
    2-keto-3-deoxy-D-glucarate aldolase
    5-dehydro-4-deoxy-D-glucarate aldolase
    Alpha-keto-beta-deoxy-D-glucarate aldolase

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:garL

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Homohexamer; trimer of dimers.

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

  • Pathwayi: galactarate degradation

    This protein is involved in step 2 of the subpathway that synthesizes D-glycerate from galactarate. This subpathway is part of the pathway galactarate degradation, which is itself part of Carbohydrate acid metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glycerate from galactarate, the pathway galactarate degradation and in Carbohydrate acid metabolism.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Substrate (to residues corresponding to position 179)
  • Substrate (to residues corresponding to position 151)
  • Substrate; via amide nitrogen (to residues corresponding to position 178)

<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei

  • Increases basicity of active site His (to residues corresponding to position 89)
  • Transition state stabilizer (to residues corresponding to position 75)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Magnesium (to residues corresponding to position 153)
  • Magnesium (to residues corresponding to position 179)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Proton acceptor (to residues corresponding to position 50)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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