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The annotation and conditions in this rule are derived from the following entries: P0A731 (MGSA_ECOLI)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 19 - 19 aligns to "H" in entry P0A731 (individually applies "Substrate")
    • Subsequence at position 23 - 23 aligns to "K" in entry P0A731 (individually applies "Substrate")
    • Subsequence at position 45 - 48 aligns to "T-G-[TAS]-T" in entry P0A731 (individually applies "Substrate binding")
    • Subsequence at position 65 - 66 aligns to "S-G" in entry P0A731 (individually applies "Substrate binding")
    • Subsequence at position 71 - 71 aligns to "D" in entry P0A731 (individually applies "Proton donor/acceptor")
    • Subsequence at position 98 - 98 aligns to "H" in entry P0A731 (individually applies "Substrate")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Methylglyoxal synthase (EC:4.2.3.3)
    Short name:
    MGS

Gene namei

  • Name:mgsA

Functioni

  • Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

Catalytic activityi

  • Glycerone phosphate = methylglyoxal + phosphate.

Sequence similaritiesi

Regioni

  • Substrate binding (to residues corresponding to positions 45 - 48)
  • Substrate binding (to residues corresponding to positions 65 - 66)

Active sitei

  • Proton donor/acceptor (to residues corresponding to position 71)

Binding sitei

  • Substrate (to residues corresponding to position 19)
  • Substrate (to residues corresponding to position 23)
  • Substrate (to residues corresponding to position 98)

Keywordi

GO (Gene Ontology) termsi

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