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The annotation and conditions in this rule are derived from the following entries: Q46DY5 (FAEHP_METBF), Q58842 (FAEHP_METJA)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01268
    • taxon = Archaea
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 83 - 83 aligns to "Q" in entry Q46DY5 (individually applies "Substrate")
    • Subsequence at position 19 - 19 aligns to "D" in entry Q46DY5 (individually applies "Substrate")
    • Subsequence at position @NTER@ - 161 aligns to entry Q46DY5 (individually applies "Formaldehyde-activating enzyme")
    • Subsequence at position 17 - 17 aligns to "H" in entry Q46DY5 (individually applies "Proton donor")
    • Subsequence at position 66 - 66 aligns to "K" in entry Q46DY5 (individually applies "Substrate")
    • Subsequence at position 162 - @CTER@ aligns to entry Q46DY5 (individually applies "3-hexulose-6-phosphate synthase")
    • Subsequence at position 68 - 68 aligns to "T" in entry Q46DY5 (individually applies "Substrate")
    • Subsequence at position 48 - 48 aligns to "L" in entry Q46DY5 (individually applies "Substrate; via carbonyl oxygen")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

  • Recommended name:
    Bifunctional enzyme Fae/Hps

Cleaved chain(s) or included domain(s)i

  • Includes domain:
    Recommended name:
    5,6,7,8-tetrahydromethanopterin hydro-lyase (EC:4.2.1.147)
    Alternative name(s):
    Formaldehyde-activating enzyme
    Short name:
    Fae
  • Includes domain:
    Recommended name:
    3-hexulose-6-phosphate synthase (EC:4.1.2.43)
    Short name:
    HPS
    Alternative name(s):
    D-arabino-3-hexulose-6-phosphate formaldehyde lyase

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:fae-hps

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

  • Pathwayi: D-ribose 5-phosphate biosynthesis

    This protein is involved in the pathway D-ribose 5-phosphate biosynthesis, which is part of Carbohydrate biosynthesis.
    View all proteins of this organism that are known to be involved in the pathway D-ribose 5-phosphate biosynthesis and in Carbohydrate biosynthesis.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H4MPT) to 5,10-methylenetetrahydromethanopterin.
  • Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.

<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni

  • Formaldehyde-activating enzyme (to residues corresponding to positions @NTER@i - 161)
  • 3-hexulose-6-phosphate synthase (to residues corresponding to positions 162 - @CTER@i)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Proton donor (to residues corresponding to position 17)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Substrate (to residues corresponding to position 83)
  • Substrate (to residues corresponding to position 19)
  • Substrate (to residues corresponding to position 66)
  • Substrate (to residues corresponding to position 68)
  • Substrate; via carbonyl oxygen (to residues corresponding to position 48)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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