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The annotation and conditions in this rule are derived from the following entries: P06993 (MALT_ECOLI)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 39 - 46 aligns to "x-P-[AS]-G-[YF]-G-K-[TS]" in entry P06993

... then these annotations are applied i

Protein namei

  • Recommended name:
    HTH-type transcriptional regulator MalT
    Alternative name(s):
    ATP-dependent transcriptional activator MalT

Gene namei

  • Name:malT

Subunit structurei

  • Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.

Enzyme regulationi

  • Activated by ATP and maltotriose, which are both required for DNA binding.


  • Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.

Sequence similaritiesi

Nucleotide bindingi

  • ATP (to residues corresponding to positions 39 - 46)


GO (Gene Ontology) termsi

  • GO:0003700 DNA binding transcription factor activity
  • GO:0005524 ATP binding
  • GO:0045893 positive regulation of transcription, DNA-templated
  • GO:0045913 positive regulation of carbohydrate metabolic process

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