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The annotation and conditions in this rule are derived from the following entries: P70881 (UPP_BACCL), P0A8F0 (UPP_ECOLI), Q980Q4 (UPP_SACS2), P39149 (UPP_BACSU)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01218_A
    • taxon = Archaea
    • fragment ≠ the sequence is fragmented

Special conditions

    • taxon = Bacteria
    • Subsequence at position 131 - 139 aligns to entry P70881 (individually applies "5-phospho-alpha-D-ribose 1-diphosphate binding")
    • Subsequence at position 79 - 79 aligns to "R" in entry P70881 (individually applies "5-phospho-alpha-D-ribose 1-diphosphate")
    • Subsequence at position 194 - 194 aligns to "[IV]" in entry P70881 (individually applies "Uracil; via amide nitrogen")
    • Subsequence at position 199 - 201 aligns to "G-x-[AIC]" in entry P70881 (individually applies "Uracil binding")
    • Subsequence at position 104 - 104 aligns to "[RK]" in entry P70881 (individually applies "5-phospho-alpha-D-ribose 1-diphosphate")
    • Subsequence at position 200 - 200 aligns to "D" in entry P70881 (individually applies "5-phospho-alpha-D-ribose 1-diphosphate")
    • taxon = Archaea
    • Subsequence at position 30 - 34 aligns to "[KR]-x(3)-[RK]" in entry Q980Q4 (individually applies "GTP")
    • Subsequence at position 105 - 105 aligns to "[RK]" in entry Q980Q4 (individually applies "5-phospho-alpha-D-ribose 1-diphosphate")
    • Subsequence at position 80 - 80 aligns to "R" in entry Q980Q4 (individually applies "5-phospho-alpha-D-ribose 1-diphosphate")
    • Subsequence at position 203 - 203 aligns to "[IV]" in entry Q980Q4 (individually applies "Uracil; via amide nitrogen")
    • Subsequence at position 209 - 209 aligns to "D" in entry Q980Q4 (individually applies "5-phospho-alpha-D-ribose 1-diphosphate")
    • Subsequence at position 140 - 148 aligns to entry Q980Q4 (individually applies "5-phospho-alpha-D-ribose 1-diphosphate binding")
    • Subsequence at position 208 - 210 aligns to "G-x-[AIC]" in entry Q980Q4 (individually applies "Uracil binding")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:upp

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

  • Allosterically activated by GTP.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

  • Pathwayi: UMP biosynthesis via salvage pathway

    This protein is involved in step 1 of the subpathway that synthesizes UMP from uracil. This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uracil, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi

  • GTP (to residues corresponding to positions 30 - 34)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • 5-phospho-alpha-D-ribose 1-diphosphate (to residues corresponding to position 79)
  • Uracil; via amide nitrogen (to residues corresponding to position 194)
  • 5-phospho-alpha-D-ribose 1-diphosphate (to residues corresponding to position 104)
  • 5-phospho-alpha-D-ribose 1-diphosphate (to residues corresponding to position 200)
  • 5-phospho-alpha-D-ribose 1-diphosphate (to residues corresponding to position 105)
  • 5-phospho-alpha-D-ribose 1-diphosphate (to residues corresponding to position 80)
  • Uracil; via amide nitrogen (to residues corresponding to position 203)
  • 5-phospho-alpha-D-ribose 1-diphosphate (to residues corresponding to position 209)

<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni

  • 5-phospho-alpha-D-ribose 1-diphosphate binding (to residues corresponding to positions 131 - 139)
  • Uracil binding (to residues corresponding to positions 199 - 201)
  • 5-phospho-alpha-D-ribose 1-diphosphate binding (to residues corresponding to positions 140 - 148)
  • Uracil binding (to residues corresponding to positions 208 - 210)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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