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The annotation and conditions in this rule are derived from the following entries: P10724 (ALR_GEOSE), Q9RER4 (ALR_AQUPY), Q9S5V6 (ALR_BACPS), P10725 (ALR1_BACSU), P0A6B4 (ALR1_ECOLI), P29012 (ALR2_ECOLI), O30746 (ALR2_KLEAE), Q9FCV2 (ALR_LACRE), G2K4Q7 (ALR_LISM4), Q9L888 (ALR_MYCAV), P94967 (ALR_MYCSM), P9WQA9 (ALR_MYCTU), Q9HUN4 (ALR1_PSEAE), Q9HTQ2 (ALR2_PSEAE), P33162 (ALR_PSEFL), Q9RAE7 (ALR2_RHIL3), P0A1A3 (ALR1_SALTY), P06191 (ALR2_SALTY), Q932V0 (ALR1_SHIDY), Q93HP9 (ALR1_SHISO)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 39 - 39 aligns to "K" in entry P10724 (individually applies "N6-(pyridoxal phosphate)lysine")
    • Subsequence at position 312 - 312 aligns to "M" in entry P10724 (individually applies "Substrate; via amide nitrogen")
    • Subsequence at position 265 - 265 aligns to "Y" in entry P10724 (individually applies "Proton acceptor; specific for L-alanine")
    • Subsequence at position 136 - 136 aligns to "R" in entry P10724 (individually applies "Substrate")
    • Subsequence at position 39 - 39 aligns to "K" in entry P10724 (individually applies "Proton acceptor; specific for D-alanine")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

  • Pathwayi: D-alanine biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine. This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Proton acceptor; specific for L-alanine (to residues corresponding to position 265)
  • Proton acceptor; specific for D-alanine (to residues corresponding to position 39)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Substrate; via amide nitrogen (to residues corresponding to position 312)
  • Substrate (to residues corresponding to position 136)

<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei

  • N6-(pyridoxal phosphate)lysine (to residues corresponding to position 39)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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