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The annotation and conditions in this rule are derived from the following entries: P10724 (ALR_GEOSE), Q9RER4 (ALR_AQUPY), Q9S5V6 (ALR_BACPS), P10725 (ALR1_BACSU), P0A6B4 (ALR1_ECOLI), P29012 (ALR2_ECOLI), O30746 (ALR2_KLEAE), Q9FCV2 (ALR_LACRE), G2K4Q7 (ALR_LISM4), Q9L888 (ALR_MYCAV), P94967 (ALR_MYCSM), P9WQA9 (ALR_MYCTU), Q9HUN4 (ALR1_PSEAE), Q9HTQ2 (ALR2_PSEAE), P33162 (ALR_PSEFL), Q9RAE7 (ALR2_RHIL3), P0A1A3 (ALR1_SALTY), P06191 (ALR2_SALTY), Q932V0 (ALR1_SHIDY), Q93HP9 (ALR1_SHISO)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 39 - 39 aligns to "K" in entry P10724 (individually applies "Proton acceptor; specific for D-alanine")
    • Subsequence at position 39 - 39 aligns to "K" in entry P10724 (individually applies "N6-(pyridoxal phosphate)lysine")
    • Subsequence at position 136 - 136 aligns to "R" in entry P10724 (individually applies "Substrate")
    • Subsequence at position 265 - 265 aligns to "Y" in entry P10724 (individually applies "Proton acceptor; specific for L-alanine")
    • Subsequence at position 312 - 312 aligns to "M" in entry P10724 (individually applies "Substrate; via amide nitrogen")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Alanine racemase (EC:5.1.1.1)

Functioni

  • Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

Cofactori

Pathwayi

  • Pathwayi: D-alanine biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine. This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sequence similaritiesi

Catalytic activityi

  • L-alanine = D-alanine.

Modified residuei

  • N6-(pyridoxal phosphate)lysine (to residues corresponding to position 39)

Active sitei

  • Proton acceptor; specific for D-alanine (to residues corresponding to position 39)
  • Proton acceptor; specific for L-alanine (to residues corresponding to position 265)

Binding sitei

  • Substrate (to residues corresponding to position 136)
  • Substrate; via amide nitrogen (to residues corresponding to position 312)

Keywordsi

GO (Gene Ontology) termsi

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