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The annotation and conditions in this rule are derived from the following entries: P39371 (NANM_ECOLI)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 228 - 228 aligns to "E" in entry P39371 (individually applies "Proton acceptor")
    • Subsequence at position 338 - 367 aligns to entry P39371 (individually applies "Kelch 7")
    • Subsequence at position 139 - 173 aligns to entry P39371 (individually applies "Kelch 3")
    • Subsequence at position 86 - 137 aligns to entry P39371 (individually applies "Kelch 2")
    • Subsequence at position 222 - 265 aligns to entry P39371 (individually applies "Kelch 5")
    • Subsequence at position 40 - 84 aligns to entry P39371 (individually applies "Kelch 1")
    • Subsequence at position 174 - 219 aligns to entry P39371 (individually applies "Kelch 4")
    • Subsequence at position 287 - 336 aligns to entry P39371 (individually applies "Kelch 6")
    • Predicted signal

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

  • Recommended name:
    N-acetylneuraminate epimerase (EC:5.1.3.24)
    Alternative name(s):
    N-acetylneuraminate mutarotase
    Short name:
    Neu5Ac mutarotase
    Sialic acid epimerase

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:nanM

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Homodimer.

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati

  • Kelch 7 (to residues corresponding to positions 338 - 367)
  • Kelch 3 (to residues corresponding to positions 139 - 173)
  • Kelch 2 (to residues corresponding to positions 86 - 137)
  • Kelch 5 (to residues corresponding to positions 222 - 265)
  • Kelch 1 (to residues corresponding to positions 40 - 84)
  • Kelch 4 (to residues corresponding to positions 174 - 219)
  • Kelch 6 (to residues corresponding to positions 287 - 336)

<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>Chaini

  • @CHAIN_NAME@i (to residues corresponding to positions @TO|+1@i - @CTER@i)

<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei

  • (to residues corresponding to positions @NTER@i - @TO@i)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Proton acceptor (to residues corresponding to position 228)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

  • GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives
  • GO:0042597 periplasmic space
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