Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniRule: UR000100757

Source Rule HAMAP: MF_01139

View all proteins annotated by this ruleRemove highlights

The annotation and conditions in this rule are derived from the following entries: P60472 (UPPS_ECOLI), O82827 (UPPS_MICLU), Q9HH76 (UPPS_SULAC), P9WFF7 (DPDS_MYCTU), A0R0S4 (DPDS_MYCS2), P9WFF5 (ZFPP_MYCTU), A0R2W4 (ZFPP_MYCS2), Q47SS3 (ZFPP_THEFY), Q47RM6 (DPDP_THEFY)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 39 - 39 aligns to "[RK]" in entry P60472 (individually applies "Substrate")
    • Subsequence at position 74 - 74 aligns to "N" in entry P60472 (individually applies "Proton acceptor")
    • Subsequence at position 75 - 75 aligns to "[WF]" in entry P60472 (individually applies "Substrate")
    • Subsequence at position 77 - 77 aligns to "[RK]" in entry P60472 (individually applies "Substrate")
    • Subsequence at position 43 - 43 aligns to "H" in entry P60472 (individually applies "Substrate")
    • Subsequence at position 71 - 73 aligns to "S-x-[ED]" in entry P60472 (individually applies "Substrate binding")
    • Subsequence at position 26 - 26 aligns to "D" in entry P60472 (individually applies "")
    • Subsequence at position 194 - 194 aligns to "R" in entry P60472 (individually applies "Substrate")
    • Subsequence at position 213 - 213 aligns to "E" in entry P60472 (individually applies "Magnesium")
    • Subsequence at position 31 - 31 aligns to "[WF]" in entry P60472 (individually applies "Substrate")
    • Subsequence at position 26 - 26 aligns to "D" in entry P60472 (individually applies "Magnesium")
    • Subsequence at position 27 - 30 aligns to "G-N-x-[RK]" in entry P60472 (individually applies "Substrate binding")
    • Subsequence at position 200 - 202 aligns to "R-x-S" in entry P60472 (individually applies "Substrate binding")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi

  • Recommended name:
    Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) (EC:2.5.1.89)
    Alternative name(s):
    Undecaprenyl diphosphate synthase
    Short name:
    UDS
    Undecaprenyl pyrophosphate synthase
    Short name:
    UPP synthase
  • Recommended name:
    Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) (EC:2.5.1.31)
    Alternative name(s):
    Ditrans,polycis-undecaprenylcistransferase
    Undecaprenyl diphosphate synthase
    Short name:
    UDS
    Undecaprenyl pyrophosphate synthase
    Short name:
    UPP synthase
  • Recommended name:
    Isoprenyl transferase (EC:2.5.1.-)

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:uppS

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
  • Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
  • Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Homodimer.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Proton acceptor (to residues corresponding to position 74)
  • (to residues corresponding to position 26)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Substrate (to residues corresponding to position 39)
  • Substrate (to residues corresponding to position 75)
  • Substrate (to residues corresponding to position 77)
  • Substrate (to residues corresponding to position 43)
  • Substrate (to residues corresponding to position 194)
  • Substrate (to residues corresponding to position 31)

<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni

  • Substrate binding (to residues corresponding to positions 71 - 73)
  • Substrate binding (to residues corresponding to positions 27 - 30)
  • Substrate binding (to residues corresponding to positions 200 - 202)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Magnesium (to residues corresponding to position 213)
  • Magnesium (to residues corresponding to position 26)
  • Magnesium (to residues corresponding to position 199)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again