UniRule: UR000100757
Source Rule HAMAP: MF_01139
The annotation and conditions in this rule are derived from the following entries: P60472 (UPPS_ECOLI), O82827 (UPPS_MICLU), Q9HH76 (UPPS_SULAC), P9WFF7 (DPDS_MYCTU), A0R0S4 (DPDS_MYCS2), P9WFF5 (ZFPP_MYCTU), A0R2W4 (ZFPP_MYCS2), Q47SS3 (ZFPP_THEFY), Q47RM6 (DPDP_THEFY)
If a protein meets these conditions... i
Common conditions
Special conditions
- taxon = Archaea
- taxon = Gammaproteobacteria
- taxon ≠ Archaea, Gammaproteobacteria
- Subsequence at position 39 - 39 aligns to "[RK]" in entry P60472 (individually applies "Substrate")
- Subsequence at position 74 - 74 aligns to "N" in entry P60472 (individually applies "Proton acceptor")
- Subsequence at position 75 - 75 aligns to "[WF]" in entry P60472 (individually applies "Substrate")
- Subsequence at position 77 - 77 aligns to "[RK]" in entry P60472 (individually applies "Substrate")
- Subsequence at position 43 - 43 aligns to "H" in entry P60472 (individually applies "Substrate")
- Subsequence at position 71 - 73 aligns to "S-x-[ED]" in entry P60472 (individually applies "Substrate binding")
- Subsequence at position 26 - 26 aligns to "D" in entry P60472 (individually applies "")
- Subsequence at position 194 - 194 aligns to "R" in entry P60472 (individually applies "Substrate")
- Subsequence at position 213 - 213 aligns to "E" in entry P60472 (individually applies "Magnesium")
- Subsequence at position 31 - 31 aligns to "[WF]" in entry P60472 (individually applies "Substrate")
- Subsequence at position 26 - 26 aligns to "D" in entry P60472 (individually applies "Magnesium")
- Subsequence at position 27 - 30 aligns to "G-N-x-[RK]" in entry P60472 (individually applies "Substrate binding")
- Subsequence at position 200 - 202 aligns to "R-x-S" in entry P60472 (individually applies "Substrate binding")
- taxon = Enterobacterales
- Subsequence at position 199 - 199 aligns to "H" in entry P60472
... then these annotations are applied i
Protein namesi
- Recommended name:Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) (EC:2.5.1.89)Alternative name(s):Undecaprenyl diphosphate synthaseShort name:UDSUndecaprenyl pyrophosphate synthaseShort name:UPP synthase
- Recommended name:Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) (EC:2.5.1.31)Alternative name(s):Ditrans,polycis-undecaprenylcistransferaseUndecaprenyl diphosphate synthaseShort name:UDSUndecaprenyl pyrophosphate synthaseShort name:UPP synthase
- Recommended name:Isoprenyl transferase (EC:2.5.1.-)
Gene namei
- Name:uppS
Cofactori
- Mg2+Note: Binds 2 magnesium ions per subunit.
Functioni
- Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
- Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
- Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
Catalytic activityi
Sequence similaritiesi
- Belongs to the UPP synthase family.
Subunit structurei
- Homodimer.
Active sitei
- Proton acceptor (to residues corresponding to position 74)
- (to residues corresponding to position 26)
Binding sitei
- Substrate (to residues corresponding to position 39)
- Substrate (to residues corresponding to position 75)
- Substrate (to residues corresponding to position 77)
- Substrate (to residues corresponding to position 43)
- Substrate (to residues corresponding to position 194)
- Substrate (to residues corresponding to position 31)
Regioni
- Substrate binding (to residues corresponding to positions 71 - 73)
- Substrate binding (to residues corresponding to positions 27 - 30)
- Substrate binding (to residues corresponding to positions 200 - 202)
Metal bindingi
- Magnesium (to residues corresponding to position 213)
- Magnesium (to residues corresponding to position 26)
- Magnesium (to residues corresponding to position 199)
Keywordsi
GO (Gene Ontology) termsi
- GO:0000287 magnesium ion binding
- GO:0004659 prenyltransferase activity
- GO:0008834 di-trans,poly-cis-decaprenylcistransferase activity
- GO:0009252 peptidoglycan biosynthetic process