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The annotation and conditions in this rule are derived from the following entries: P27550 (ACSA_ECOLI), Q8ZKF6 (ACSA_SALTY), P9WQD1 (ACSA_MYCTU)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 191 - 194 aligns to "[RY]-[AGRKN]-[GSNDP]-x" in entry Q8ZKF6 (individually applies "Coenzyme A binding")
    • Subsequence at position 311 - 311 aligns to "[TS]" in entry Q8ZKF6 (individually applies "Coenzyme A")
    • Subsequence at position 335 - 335 aligns to "N" in entry Q8ZKF6 (individually applies "Coenzyme A")
    • Subsequence at position 387 - 389 aligns to "G-[ES]-[PG]" in entry Q8ZKF6 (individually applies "ATP")
    • Subsequence at position 411 - 416 aligns to "[DS]-T-[WF]-W-[QM]-T" in entry Q8ZKF6 (individually applies "ATP")
    • Subsequence at position 500 - 500 aligns to "D" in entry Q8ZKF6 (individually applies "ATP")
    • Subsequence at position 515 - 515 aligns to "R" in entry Q8ZKF6 (individually applies "ATP")
    • Subsequence at position 523 - 523 aligns to "S" in entry Q8ZKF6 (individually applies "Coenzyme A; via carbonyl oxygen")
    • Subsequence at position 526 - 526 aligns to "R" in entry Q8ZKF6 (individually applies "ATP")
    • Subsequence at position 537 - 537 aligns to "V" in entry Q8ZKF6 (individually applies "Magnesium; via carbonyl oxygen")
    • Subsequence at position 539 - 539 aligns to "[HF]" in entry Q8ZKF6 (individually applies "Magnesium; via carbonyl oxygen")
    • Subsequence at position 542 - 542 aligns to "[IV]" in entry Q8ZKF6 (individually applies "Magnesium; via carbonyl oxygen")
    • Subsequence at position 584 - 584 aligns to "R" in entry Q8ZKF6 (individually applies "Coenzyme A")
    • Subsequence at position 609 - 609 aligns to "K" in entry Q8ZKF6 (individually applies "N6-acetyllysine")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Acetyl-coenzyme A synthetase (EC:6.2.1.1)
    Short name:
    AcCoA synthetase
    Short name:
    Acs
    Alternative name(s):
    Acetate--CoA ligase
    Acyl-activating enzyme

Gene namesi

  • Name:acs
  • Name:acsA

Sequence similaritiesi

Cofactori

Post-translational modificationi

  • Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.

Functioni

  • Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
  • Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis.
  • Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

Catalytic activityi

  • ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Regioni

  • Coenzyme A binding (to residues corresponding to positions 191 - 194)

Metal bindingi

  • Magnesium; via carbonyl oxygen (to residues corresponding to position 537)
  • Magnesium; via carbonyl oxygen (to residues corresponding to position 539)
  • Magnesium; via carbonyl oxygen (to residues corresponding to position 542)

Nucleotide bindingi

  • ATP (to residues corresponding to positions 387 - 389)
  • ATP (to residues corresponding to positions 411 - 416)

Binding sitei

  • Coenzyme A (to residues corresponding to position 311)
  • Coenzyme A (to residues corresponding to position 335)
  • ATP (to residues corresponding to position 500)
  • ATP (to residues corresponding to position 515)
  • Coenzyme A; via carbonyl oxygen (to residues corresponding to position 523)
  • ATP (to residues corresponding to position 526)
  • Coenzyme A (to residues corresponding to position 584)

Modified residuei

  • N6-acetyllysine (to residues corresponding to position 609)

Keywordsi

GO (Gene Ontology) termsi

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