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The annotation and conditions in this rule are derived from the following entries: P04391 (OTC1_ECOLI), P9WIT9 (OTC_MYCTU), Q8DCF5 (OTC_VIBVU)

If a protein meets these conditions... i

Common conditions

Special conditions

    • proteome property = ARGININE_BS=Yes
    • proteome property = ARGININE_BS=No
    • proteome property = ARGININE_BS=Yes
    • proteome property ≠ ARGININE_BS=*
    • Subsequence at position 56 - 59 aligns to "S-[TS]-R-T" in entry P04391 (individually applies "Carbamoyl phosphate binding")
    • Subsequence at position 83 - 83 aligns to "[QN]" in entry P04391 (individually applies "Carbamoyl phosphate")
    • Subsequence at position 107 - 107 aligns to "R" in entry P04391 (individually applies "Carbamoyl phosphate")
    • Subsequence at position 134 - 137 aligns to "H-x(2)-Q" in entry P04391 (individually applies "Carbamoyl phosphate binding")
    • Subsequence at position 168 - 168 aligns to "N" in entry P04391 (individually applies "Ornithine")
    • Subsequence at position 232 - 232 aligns to "D" in entry P04391 (individually applies "Ornithine")
    • Subsequence at position 236 - 237 aligns to "S-[MIL]" in entry P04391 (individually applies "Ornithine binding")
    • Subsequence at position 274 - 275 aligns to "C-L" in entry P04391 (individually applies "Carbamoyl phosphate binding")
    • Subsequence at position 320 - 320 aligns to "[RK]" in entry P04391 (individually applies "Carbamoyl phosphate")

... then these annotations are applied i

Protein namesi

  • Recommended name:
    Ornithine carbamoyltransferase, catabolic (EC:2.1.3.3)
    Short name:
    OTCase
  • Recommended name:
    Ornithine carbamoyltransferase (EC:2.1.3.3)
    Short name:
    OTCase

Gene namesi

  • Name:arcB
  • Name:argI
  • Name:argF

Subcellular locationi

Catalytic activityi

  • Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Sequence similaritiesi

Pathwayi

  • Pathwayi: L-arginine biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate. This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.
  • Pathwayi: L-arginine degradation via ADI pathway

    This protein is involved in step 2 of the subpathway that synthesizes carbamoyl phosphate from L-arginine. This subpathway is part of the pathway L-arginine degradation via ADI pathway, which is itself part of Amino-acid degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes carbamoyl phosphate from L-arginine, the pathway L-arginine degradation via ADI pathway and in Amino-acid degradation.

Regioni

  • Carbamoyl phosphate binding (to residues corresponding to positions 56 - 59)
  • Carbamoyl phosphate binding (to residues corresponding to positions 134 - 137)
  • Ornithine binding (to residues corresponding to positions 236 - 237)
  • Carbamoyl phosphate binding (to residues corresponding to positions 274 - 275)

Binding sitei

  • Carbamoyl phosphate (to residues corresponding to position 83)
  • Carbamoyl phosphate (to residues corresponding to position 107)
  • Ornithine (to residues corresponding to position 168)
  • Ornithine (to residues corresponding to position 232)
  • Carbamoyl phosphate (to residues corresponding to position 320)

Keywordsi

GO (Gene Ontology) termsi

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