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The annotation and conditions in this rule are derived from the following entries: Q07908 (ARGJ_GEOSE), P9WPZ3 (ARGJ_MYCTU), Q9Z4S1 (ARGJ_THENN), P0DJQ5 (GNAT2_STRCL), Q9K8V3 (ARGJ_BACHD)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01106
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented
    • Matches HAMAP signature MF_01106
    • taxon = Archaea
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 166 - 166 aligns to "T" in entry P9WPZ3 (individually applies "Substrate")
    • Subsequence at position 189 - 189 aligns to "K" in entry P9WPZ3 (individually applies "Substrate")
    • Subsequence at position 128 - 128 aligns to "G" in entry P9WPZ3 (individually applies "Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole")
    • Subsequence at position 200 - @CTER@ aligns to entry P9WPZ3 (individually applies "Arginine biosynthesis bifunctional protein ArgJ beta chain")
    • Subsequence at position 280 - 280 aligns to "E" in entry P9WPZ3 (individually applies "Substrate")
    • Subsequence at position 199 - 200 aligns to "[AG]-[TS]" in entry P9WPZ3 (individually applies "Cleavage; by autolysis")
    • Subsequence at position 127 - 127 aligns to "T" in entry P9WPZ3 (individually applies "Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole")
    • Subsequence at position 200 - 200 aligns to "[TS]" in entry P9WPZ3 (individually applies "Substrate")
    • Subsequence at position 399 - 399 aligns to "N" in entry P9WPZ3 (individually applies "Substrate")
    • Subsequence at position 404 - 404 aligns to "[ST]" in entry P9WPZ3 (individually applies "Substrate")
    • Subsequence at position @NTER@ - 199 aligns to entry P9WPZ3 (individually applies "Arginine biosynthesis bifunctional protein ArgJ alpha chain")
    • Subsequence at position 200 - 200 aligns to "[TS]" in entry P9WPZ3 (individually applies "Nucleophile")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

  • Recommended name:
    Arginine biosynthesis bifunctional protein ArgJ

Cleaved chain(s) or included domain(s)i

  • Includes domain:
    Recommended name:
    Glutamate N-acetyltransferase (EC:2.3.1.35)
    Alternative name(s):
    Ornithine acetyltransferase
    Short name:
    OATase
    Ornithine transacetylase
  • Includes domain:
    Recommended name:
    Amino-acid acetyltransferase (EC:2.3.1.1)
    Alternative name(s):
    N-acetylglutamate synthase
    Short name:
    AGSase
  • Cleaved chain:
    Recommended name:
    Arginine biosynthesis bifunctional protein ArgJ alpha chain
  • Cleaved chain:
    Recommended name:
    Arginine biosynthesis bifunctional protein ArgJ beta chain

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:argJ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Heterotetramer of two alpha and two beta chains.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

<p>This subsection of the ‘Function’ section describes relevant information that doesn’t fall into the scope of any other subsections, but is thought to be valuable enough to be cited in UniProtKB.<p><a href='/help/miscellaneous' target='_top'>More...</a></p>Miscellaneousi

  • Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>Chaini

  • Arginine biosynthesis bifunctional protein ArgJ beta chain (to residues corresponding to positions 200 - @CTER@i)
  • Arginine biosynthesis bifunctional protein ArgJ alpha chain (to residues corresponding to positions @NTER@i - 199)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Substrate (to residues corresponding to position 166)
  • Substrate (to residues corresponding to position 189)
  • Substrate (to residues corresponding to position 280)
  • Substrate (to residues corresponding to position 200)
  • Substrate (to residues corresponding to position 399)
  • Substrate (to residues corresponding to position 404)

<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei

  • Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole (to residues corresponding to position 128)
  • Cleavage; by autolysis (to residues corresponding to positions 199 - 200)
  • Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole (to residues corresponding to position 127)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Nucleophile (to residues corresponding to position 200)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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