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The annotation and conditions in this rule are derived from the following entries: P60340 (TRUB_ECOLI), P9WHP7 (TRUB_MYCTU), Q9WZW0 (TRUB_THEMA)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01080
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 48 - 48 aligns to "D" in entry P60340
    • taxon = Enterobacterales
    • Subsequence at position 43 - 43 aligns to "H" in entry P60340 (individually applies "Substrate")
    • Subsequence at position 76 - 76 aligns to "Y" in entry P60340 (individually applies "Substrate")
    • Subsequence at position 179 - 179 aligns to "Y" in entry P60340 (individually applies "Substrate")
    • Subsequence at position 200 - 200 aligns to "L" in entry P60340 (individually applies "Substrate")

... then these annotations are applied i

Protein namei

  • Recommended name:
    tRNA pseudouridine synthase B (EC:5.4.99.25)
    Alternative name(s):
    tRNA pseudouridine(55) synthase
    Short name:
    Psi55 synthase
    tRNA-uridine isomerase
    tRNA pseudouridylate synthase

Gene namei

  • Name:truB

Catalytic activityi

  • tRNA uridine(55) = tRNA pseudouridine(55).

Sequence similaritiesi

Functioni

  • Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

Binding sitei

  • Substrate (to residues corresponding to position 43)
  • Substrate (to residues corresponding to position 76)
  • Substrate (to residues corresponding to position 179)
  • Substrate (to residues corresponding to position 200)

Active sitei

  • Nucleophile (to residues corresponding to position 48)

Keywordsi

GO (Gene Ontology) termsi

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