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The annotation and conditions in this rule are derived from the following entries: P06988 (HISX_ECOLI), P10370 (HISX_SALTY)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 262 - 262 aligns to "H" in entry P06988 Subsequence at position 360 - 360 aligns to "D" in entry P06988 Subsequence at position 259 - 259 aligns to "[EQ]" in entry P06988 Subsequence at position 419 - 419 aligns to "H" in entry P06988
    • Subsequence at position 326 - 326 aligns to "E" in entry P06988 (individually applies "Proton acceptor")
    • Subsequence at position 327 - 327 aligns to "H" in entry P06988 (individually applies "Proton acceptor")
  • Subsequence at position 211 - 211 aligns to "N" in entry P06988 (applies "NAD") Subsequence at position 188 - 188 aligns to "Q" in entry P06988 (applies "NAD") Subsequence at position 130 - 130 aligns to "Y" in entry P06988 (applies "NAD")
  • Subsequence at position 259 - 259 aligns to "Q" in entry P06988 (applies "Substrate") Subsequence at position 327 - 327 aligns to "H" in entry P06988 (applies "Substrate") Subsequence at position 237 - 237 aligns to "[ST]" in entry P06988 (applies "Substrate") Subsequence at position 414 - 414 aligns to "E" in entry P06988 (applies "Substrate") Subsequence at position 360 - 360 aligns to "D" in entry P06988 (applies "Substrate") Subsequence at position 419 - 419 aligns to "H" in entry P06988 (applies "Substrate") Subsequence at position 262 - 262 aligns to "H" in entry P06988 (applies "Substrate")
  • Subsequence at position 262 - 262 aligns to "H" in entry P06988 (applies "Zinc") Subsequence at position 360 - 360 aligns to "D" in entry P06988 (applies "Zinc") Subsequence at position 259 - 259 aligns to "[EQ]" in entry P06988 (applies "Zinc") Subsequence at position 419 - 419 aligns to "H" in entry P06988 (applies "Zinc")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:hisD

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This section describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Homodimer.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Zinc (to residues corresponding to position 262)
  • Zinc (to residues corresponding to position 360)
  • Zinc (to residues corresponding to position 259)
  • Zinc (to residues corresponding to position 419)

<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Proton acceptor (to residues corresponding to position 326)
  • Proton acceptor (to residues corresponding to position 327)

<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • NAD (to residues corresponding to position 211)
  • NAD (to residues corresponding to position 188)
  • NAD (to residues corresponding to position 130)
  • Substrate (to residues corresponding to position 259)
  • Substrate (to residues corresponding to position 327)
  • Substrate (to residues corresponding to position 237)
  • Substrate (to residues corresponding to position 414)
  • Substrate (to residues corresponding to position 360)
  • Substrate (to residues corresponding to position 419)
  • Substrate (to residues corresponding to position 262)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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