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The annotation and conditions in this rule are derived from the following entries: P06986 (HIS8_ECOLI), Q9X0D0 (HIS8_THEMA)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 214 - 214 aligns to "K" in entry P06986

... then these annotations are applied i

Protein namei

  • Recommended name:
    Histidinol-phosphate aminotransferase (EC:
    Alternative name(s):
    Imidazole acetol-phosphate transaminase

Gene namei

  • Name:hisC

Catalytic activityi

  • L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.


Sequence similaritiesi


  • Pathwayi: L-histidine biosynthesis

    This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate. This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Subunit structurei

  • Homodimer.

Modified residuei

  • N6-(pyridoxal phosphate)lysine (to residues corresponding to position 214)


GO (Gene Ontology) termsi

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