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The annotation and conditions in this rule are derived from the following entries: P23003 (TRMA_ECOLI)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 239 - 239 aligns to "E" in entry P23003 (individually applies "S-adenosyl-L-methionine")
    • Subsequence at position 190 - 190 aligns to "Q" in entry P23003 (individually applies "S-adenosyl-L-methionine")
    • Subsequence at position 218 - 218 aligns to "Y" in entry P23003 (individually applies "S-adenosyl-L-methionine; via carbonyl oxygen")
    • Subsequence at position 358 - 358 aligns to "E" in entry P23003 (individually applies "Proton acceptor")
    • Subsequence at position 299 - 299 aligns to "D" in entry P23003 (individually applies "S-adenosyl-L-methionine")
    • Subsequence at position 223 - 223 aligns to "[NH]" in entry P23003 (individually applies "S-adenosyl-L-methionine")
    • Subsequence at position 324 - 324 aligns to "C" in entry P23003 (individually applies "Nucleophile")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:trmA

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Proton acceptor (to residues corresponding to position 358)
  • Nucleophile (to residues corresponding to position 324)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • S-adenosyl-L-methionine (to residues corresponding to position 239)
  • S-adenosyl-L-methionine (to residues corresponding to position 190)
  • S-adenosyl-L-methionine; via carbonyl oxygen (to residues corresponding to position 218)
  • S-adenosyl-L-methionine (to residues corresponding to position 299)
  • S-adenosyl-L-methionine (to residues corresponding to position 223)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

  • GO:0030488 tRNA methylation
  • GO:0030697 S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity
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