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The annotation and conditions in this rule are derived from the following entries: P12851 (XYLA_ACTM4), P12070 (XYLA_ARTS7), P54272 (XYLA_BACSW), P00944 (XYLA_ECOLI), P15587 (XYLA_STROL)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00455
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • taxon = Deinococci, Actinomycetales
    • Subsequence at position 54 - 54 aligns to "H" in entry P12851 (individually applies "")
    • Subsequence at position 57 - 57 aligns to "[DE]" in entry P12851 (individually applies "")
    • Subsequence at position 181 - 181 aligns to "E" in entry P12851 (individually applies "Magnesium 1")
    • Subsequence at position 217 - 217 aligns to "E" in entry P12851 (individually applies "Magnesium 1")
    • Subsequence at position 217 - 217 aligns to "E" in entry P12851 (individually applies "Magnesium 2")
    • Subsequence at position 220 - 220 aligns to "H" in entry P12851 (individually applies "Magnesium 2")
    • Subsequence at position 245 - 245 aligns to "D" in entry P12851 (individually applies "Magnesium 1")
    • Subsequence at position 255 - 255 aligns to "D" in entry P12851 (individually applies "Magnesium 2")
    • Subsequence at position 257 - 257 aligns to "D" in entry P12851 (individually applies "Magnesium 2")
    • Subsequence at position 292 - 292 aligns to "D" in entry P12851 (individually applies "Magnesium 1")
    • taxon ≠ Actinomycetales, Deinococci
    • Subsequence at position 101 - 101 aligns to "H" in entry P00944 (individually applies "")
    • Subsequence at position 104 - 104 aligns to "[DE]" in entry P00944 (individually applies "")
    • Subsequence at position 232 - 232 aligns to "E" in entry P00944 (individually applies "Magnesium 1")
    • Subsequence at position 268 - 268 aligns to "E" in entry P00944 (individually applies "Magnesium 1")
    • Subsequence at position 268 - 268 aligns to "E" in entry P00944 (individually applies "Magnesium 2")
    • Subsequence at position 271 - 271 aligns to "H" in entry P00944 (individually applies "Magnesium 2")
    • Subsequence at position 296 - 296 aligns to "D" in entry P00944 (individually applies "Magnesium 1")
    • Subsequence at position 307 - 307 aligns to "D" in entry P00944 (individually applies "Magnesium 2")
    • Subsequence at position 309 - 309 aligns to "D" in entry P00944 (individually applies "Magnesium 2")
    • Subsequence at position 339 - 339 aligns to "D" in entry P00944 (individually applies "Magnesium 1")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Xylose isomerase (EC:5.3.1.5)

Gene namei

  • Name:xylA

Sequence similaritiesi

Catalytic activityi

  • D-xylopyranose = D-xylulose.

Subunit structurei

  • Homotetramer.

Subcellular locationi

Cofactori

  • Mg2+Note: Binds 2 magnesium ions per subunit.

Metal bindingi

  • Magnesium 1 (to residues corresponding to position 181)
  • Magnesium 1 (to residues corresponding to position 217)
  • Magnesium 2 (to residues corresponding to position 217)
  • Magnesium 2 (to residues corresponding to position 220)
  • Magnesium 1 (to residues corresponding to position 245)
  • Magnesium 2 (to residues corresponding to position 255)
  • Magnesium 2 (to residues corresponding to position 257)
  • Magnesium 1 (to residues corresponding to position 292)
  • Magnesium 1 (to residues corresponding to position 232)
  • Magnesium 1 (to residues corresponding to position 268)
  • Magnesium 2 (to residues corresponding to position 268)
  • Magnesium 2 (to residues corresponding to position 271)
  • Magnesium 1 (to residues corresponding to position 296)
  • Magnesium 2 (to residues corresponding to position 307)
  • Magnesium 2 (to residues corresponding to position 309)
  • Magnesium 1 (to residues corresponding to position 339)

Active sitei

  • (to residues corresponding to position 54)
  • (to residues corresponding to position 57)
  • (to residues corresponding to position 101)
  • (to residues corresponding to position 104)

Keywordsi

GO (Gene Ontology) termsi

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