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The annotation and conditions in this rule are derived from the following entries: P0A6L2 (DAPA_ECOLI), P9WP25 (DAPA_MYCTU), Q9X1K9 (DAPA_THEMA), Q57695 (DAPA_METJA), Q6GH13 (DAPA_STAAR), Q5HG25 (DAPA_STAAC), Q9JZR4 (DAPA_NEIMB), Q9I4W3 (DAPA_PSEAE), Q07607 (DAPA_RHIML), Q8UGL3 (DAPA_AGRFC)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 203 - 203 aligns to "[IVAT]" in entry P0A6L2 (individually applies "Pyruvate; via carbonyl oxygen")
    • Subsequence at position 133 - 133 aligns to "Y" in entry P0A6L2 (individually applies "Proton donor/acceptor")
    • Subsequence at position 45 - 45 aligns to "[TS]" in entry P0A6L2 (individually applies "Pyruvate")
    • Subsequence at position 161 - 161 aligns to "K" in entry P0A6L2 (individually applies "Schiff-base intermediate with substrate")
    • Subsequence at position 107 - 107 aligns to "Y" in entry P0A6L2 (individually applies "Part of a proton relay during catalysis")
    • Subsequence at position 44 - 44 aligns to "[TS]" in entry P0A6L2 (individually applies "Part of a proton relay during catalysis")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:dapA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

<p>This subsection of the 'Function' section reports a variety of possible errors and/or grounds for confusion relevant to different aspects of the information provided on the protein. Note that errors concerning the protein sequence are reported in the <a href="http://www.uniprot.org/help/sequence%5Fcaution">'Sequence caution'</a> subsection.<p><a href='/help/caution' target='_top'>More...</a></p>Cautioni

  • Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Homodimer.
  • Homotetramer; dimer of dimers.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Pyruvate; via carbonyl oxygen (to residues corresponding to position 203)
  • Pyruvate (to residues corresponding to position 45)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Proton donor/acceptor (to residues corresponding to position 133)
  • Schiff-base intermediate with substrate (to residues corresponding to position 161)

<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei

  • Part of a proton relay during catalysis (to residues corresponding to position 107)
  • Part of a proton relay during catalysis (to residues corresponding to position 44)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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