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The annotation and conditions in this rule are derived from the following entries: P56709 (DNLI_PYRFU), Q9HHC4 (DNLI_THEKO), Q980T8 (DNLI_SACS2), Q9P9K9 (DNLI_SACSH), A2BJX6 (DNLI_HYPBU)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 247 - 247 aligns to "[DE]" in entry P56709 (individually applies "ATP")
    • Subsequence at position 249 - 249 aligns to "K" in entry P56709 (individually applies "N6-AMP-lysine intermediate")
    • Subsequence at position 254 - 254 aligns to "R" in entry P56709 (individually applies "ATP")
    • Subsequence at position 269 - 269 aligns to "R" in entry P56709 (individually applies "ATP")
    • Subsequence at position 299 - 299 aligns to "E" in entry P56709 (individually applies "ATP")
    • Subsequence at position 339 - 339 aligns to "F" in entry P56709 (individually applies "ATP")
    • Subsequence at position 414 - 414 aligns to "R" in entry P56709 (individually applies "ATP")
    • Subsequence at position 420 - 420 aligns to "K" in entry P56709 (individually applies "ATP")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi

  • Recommended name:
    Probable DNA ligase (EC:6.5.1.1)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]
  • Recommended name:
    DNA ligase (EC:6.5.1.6)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP/NAD(+)]
  • Recommended name:
    DNA ligase (EC:6.5.1.1)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:lig

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

    • ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate. EC:6.5.1.1
    • ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate. EC:6.5.1.6
    • NAD(+) + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + beta-nicotinamide D-nucleotide. EC:6.5.1.6
    • ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate. EC:6.5.1.1

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This section describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • N6-AMP-lysine intermediate (to residues corresponding to position 249)

<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • ATP (to residues corresponding to position 247)
  • ATP (to residues corresponding to position 254)
  • ATP (to residues corresponding to position 269)
  • ATP (to residues corresponding to position 299)
  • ATP (to residues corresponding to position 339)
  • ATP (to residues corresponding to position 414)
  • ATP (to residues corresponding to position 420)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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