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The annotation and conditions in this rule are derived from the following entries: P60546 (KGUA_ECOLI), P15454 (KGUA_YEAST)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00328
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 11 - 18 aligns to "[GSA]-x-[SAT]-[GA]-x-G-K-x" in entry P60546

... then these annotations are applied i

Protein namei

  • Recommended name:
    Guanylate kinase (EC:2.7.4.8)
    Alternative name(s):
    GMP kinase

Gene namei

  • Name:gmk

Functioni

  • Essential for recycling GMP and indirectly, cGMP.

Subcellular locationi

Catalytic activityi

  • ATP + GMP = ADP + GDP.

Sequence similaritiesi

Nucleotide bindingi

  • ATP (to residues corresponding to positions 11 - 18)

Keywordsi

GO (Gene Ontology) termsi

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Main funding by: National Institutes of Health

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