Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

The annotation and conditions in this rule are derived from the following entries: P60546 (KGUA_ECOLI), P15454 (KGUA_YEAST)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00328
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 11 - 18 aligns to "[GSA]-x-[SAT]-[GA]-x-G-K-x" in entry P60546

... then these annotations are applied i

Protein namei

  • Recommended name:
    Guanylate kinase (EC:
    Alternative name(s):
    GMP kinase

Gene namei

  • Name:gmk


  • Essential for recycling GMP and indirectly, cGMP.

Subcellular locationi

Catalytic activityi

  • ATP + GMP = ADP + GDP.

Sequence similaritiesi

Nucleotide bindingi

  • ATP (to residues corresponding to positions 11 - 18)


GO (Gene Ontology) termsi

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again