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The annotation and conditions in this rule are derived from the following entries: P32173 (MOBA_ECOLI)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 12 - 14 aligns to "[LFIVT]-x-G" in entry P32173 (individually applies "GTP")
    • Subsequence at position 25 - 25 aligns to "[KR]" in entry P32173 (individually applies "GTP")
    • Subsequence at position 53 - 53 aligns to "[NRHK]" in entry P32173 (individually applies "GTP")
    • Subsequence at position 71 - 71 aligns to "D" in entry P32173 (individually applies "GTP")
    • Subsequence at position 101 - 101 aligns to "D" in entry P32173 (individually applies "GTP")
    • Subsequence at position 101 - 101 aligns to "D" in entry P32173 (individually applies "Magnesium")

... then these annotations are applied i

Protein namesi

  • Recommended name:
    Molybdenum cofactor guanylyltransferase (EC:2.7.7.77)
    Short name:
    MoCo guanylyltransferase
    Alternative name(s):
    Mo-MPT guanylyltransferase
    GTP:molybdopterin guanylyltransferase
    Molybdopterin-guanine dinucleotide synthase
    Short name:
    MGD synthase
    Molybdopterin guanylyltransferase
  • Recommended name:
    Probable molybdenum cofactor guanylyltransferase (EC:2.7.7.77)
    Short name:
    MoCo guanylyltransferase
    Alternative name(s):
    Molybdopterin guanylyltransferase
    GTP:molybdopterin guanylyltransferase
    Mo-MPT guanylyltransferase
    Molybdopterin-guanine dinucleotide synthase
    Short name:
    MGD synthase

Gene namei

  • Name:mobA

Subunit structurei

  • Monomer.

Domaini

  • The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.

Subcellular locationi

Sequence similaritiesi

Catalytic activityi

  • GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.

Functioni

  • Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

Cofactori

Binding sitei

  • GTP (to residues corresponding to position 25)
  • GTP (to residues corresponding to position 53)
  • GTP (to residues corresponding to position 71)
  • GTP (to residues corresponding to position 101)

Metal bindingi

  • Magnesium (to residues corresponding to position 101)

Nucleotide bindingi

  • GTP (to residues corresponding to positions 12 - 14)

Keywordsi

GO (Gene Ontology) termsi

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Main funding by: National Institutes of Health

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