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The annotation and conditions in this rule are derived from the following entries: O84395 (DAPAT_CHLTR), Q6MDE0 (DAPAT_PARUW), Q55828 (DAPAT_SYNY3), O26158 (DAPAT_METTH), Q18T09 (DAPAT_DESHD), Q72NJ3 (DAPAT_LEPIC), Q2RK33 (DAPAT_MOOTA), Q5LC03 (DAPAT_BACFN), A3DK17 (DAPAT_CLOTH), Q7NDX4 (DAPAT_GLOVI), A0LEA5 (DAPAT_SYNFM)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 14 - 14 aligns to "Y" in entry O84395 (individually applies "Substrate")
    • Subsequence at position 41 - 41 aligns to "G" in entry O84395 (individually applies "Substrate; via amide nitrogen")
    • Subsequence at position 71 - 71 aligns to "Y" in entry O84395 (individually applies "Pyridoxal phosphate")
    • Subsequence at position 104 - 105 aligns to "[AST]-K" in entry O84395 (individually applies "Pyridoxal phosphate binding")
    • Subsequence at position 105 - 105 aligns to "K" in entry O84395 (individually applies "Substrate")
    • Subsequence at position 128 - 128 aligns to "[YF]" in entry O84395 (individually applies "Pyridoxal phosphate")
    • Subsequence at position 128 - 128 aligns to "[YF]" in entry O84395 (individually applies "Substrate")
    • Subsequence at position 174 - 174 aligns to "N" in entry O84395 (individually applies "Pyridoxal phosphate")
    • Subsequence at position 174 - 174 aligns to "N" in entry O84395 (individually applies "Substrate")
    • Subsequence at position 205 - 205 aligns to "Y" in entry O84395 (individually applies "Pyridoxal phosphate")
    • Subsequence at position 233 - 235 aligns to "S-x-S" in entry O84395 (individually applies "Pyridoxal phosphate binding")
    • Subsequence at position 236 - 236 aligns to "K" in entry O84395 (individually applies "N6-(pyridoxal phosphate)lysine")
    • Subsequence at position 244 - 244 aligns to "R" in entry O84395 (individually applies "Pyridoxal phosphate")
    • Subsequence at position 275 - 275 aligns to "N" in entry O84395 (individually applies "Pyridoxal phosphate")
    • Subsequence at position 275 - 275 aligns to "N" in entry O84395 (individually applies "Substrate")
    • Subsequence at position 369 - 369 aligns to "R" in entry O84395 (individually applies "Substrate")

... then these annotations are applied i

Protein namei

  • Recommended name:
    LL-diaminopimelate aminotransferase (EC:2.6.1.83)
    Short name:
    DAP-AT
    Short name:
    DAP-aminotransferase
    Short name:
    LL-DAP-aminotransferase

Gene namei

  • Name:dapL

Pathwayi

Catalytic activityi

  • LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.

Subunit structurei

  • Homodimer.

Sequence similaritiesi

Cofactori

Functioni

  • Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.

Binding sitei

  • Substrate (to residues corresponding to position 14)
  • Substrate; via amide nitrogen (to residues corresponding to position 41)
  • Pyridoxal phosphate (to residues corresponding to position 71)
  • Substrate (to residues corresponding to position 105)
  • Pyridoxal phosphate (to residues corresponding to position 128)
  • Substrate (to residues corresponding to position 128)
  • Pyridoxal phosphate (to residues corresponding to position 174)
  • Substrate (to residues corresponding to position 174)
  • Pyridoxal phosphate (to residues corresponding to position 205)
  • Pyridoxal phosphate (to residues corresponding to position 244)
  • Pyridoxal phosphate (to residues corresponding to position 275)
  • Substrate (to residues corresponding to position 275)
  • Substrate (to residues corresponding to position 369)

Modified residuei

  • N6-(pyridoxal phosphate)lysine (to residues corresponding to position 236)

Regioni

  • Pyridoxal phosphate binding (to residues corresponding to positions 104 - 105)
  • Pyridoxal phosphate binding (to residues corresponding to positions 233 - 235)

Keywordsi

GO (Gene Ontology) termsi

  • GO:0010285 L,L-diaminopimelate aminotransferase activity
  • GO:0030170 pyridoxal phosphate binding
  • GO:0033362 lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway
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