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The annotation and conditions in this rule are derived from the following entries: P60716 (LIPA_ECOLI), O32129 (LIPA_BACSU), P9WK91 (LIPA_MYCTU), Q8DLC2 (LIPA2_THEEB), Q97U63 (LIPA_SACS2)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 81 - 81 aligns to "C" in entry P9WK91 (individually applies "Iron-sulfur 2 (4Fe-4S-S-AdoMet)")
    • Subsequence at position 85 - 85 aligns to "C" in entry P9WK91 (individually applies "Iron-sulfur 2 (4Fe-4S-S-AdoMet)")
    • Subsequence at position 292 - 292 aligns to "S" in entry P9WK91 (individually applies "Iron-sulfur 1 (4Fe-4S)")
    • Subsequence at position 66 - 66 aligns to "C" in entry P9WK91 (individually applies "Iron-sulfur 1 (4Fe-4S)")
    • Subsequence at position 60 - 60 aligns to "C" in entry P9WK91 (individually applies "Iron-sulfur 1 (4Fe-4S)")
    • Subsequence at position 55 - 55 aligns to "C" in entry P9WK91 (individually applies "Iron-sulfur 1 (4Fe-4S)")
    • Subsequence at position 88 - 88 aligns to "C" in entry P9WK91 (individually applies "Iron-sulfur 2 (4Fe-4S-S-AdoMet)")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

  • Recommended name:
    Lipoyl synthase (EC:2.8.1.8)
    Alternative name(s):
    Lip-syn
    Short name:
    LS
    Lipoate synthase
    Lipoic acid synthase
    Sulfur insertion protein LipA

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:lipA

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

  • Pathwayi: protein lipoylation via endogenous pathway

    This protein is involved in the subpathway that synthesizes protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]. This subpathway is part of the pathway protein lipoylation via endogenous pathway, which is itself part of Protein modification.
    View all proteins of this organism that are known to be involved in the pathway protein lipoylation via endogenous pathway and in Protein modification.
  • Pathwayi: protein lipoylation via endogenous pathway

    This protein is involved in step 2 of the subpathway that synthesizes protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]. This subpathway is part of the pathway protein lipoylation via endogenous pathway, which is itself part of Protein modification.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein], the pathway protein lipoylation via endogenous pathway and in Protein modification.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Iron-sulfur 2 (4Fe-4S-S-AdoMet) (to residues corresponding to position 81)
  • Iron-sulfur 2 (4Fe-4S-S-AdoMet) (to residues corresponding to position 85)
  • Iron-sulfur 1 (4Fe-4S) (to residues corresponding to position 292)
  • Iron-sulfur 1 (4Fe-4S) (to residues corresponding to position 66)
  • Iron-sulfur 1 (4Fe-4S) (to residues corresponding to position 60)
  • Iron-sulfur 1 (4Fe-4S) (to residues corresponding to position 55)
  • Iron-sulfur 2 (4Fe-4S-S-AdoMet) (to residues corresponding to position 88)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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