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The annotation and conditions in this rule are derived from the following entries: P56981 (UVRB_BACCA), P0A8F8 (UVRB_ECOLI), Q56243 (UVRB_THET8)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 39 - 46 aligns to "G-[IVAT]-T-G-[ST]-G-K-[ST]" in entry P0A8F8 (individually applies "ATP")
    • Subsequence at position 92 - 115 aligns to entry P0A8F8 (individually applies "Beta-hairpin")

... then these annotations are applied i

Protein namei

  • Recommended name:
    UvrABC system protein B
    Short name:
    Protein UvrB
    Alternative name(s):
    Excinuclease ABC subunit B

Gene namei

  • Name:uvrB

Domaini

  • The beta-hairpin motif is involved in DNA binding.

Subunit structurei

  • Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.

Subcellular locationi

Sequence similaritiesi

Functioni

  • The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.

Motifi

  • Beta-hairpin (to residues corresponding to positions 92 - 115)

Nucleotide bindingi

  • ATP (to residues corresponding to positions 39 - 46)

Keywordsi

GO (Gene Ontology) termsi

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