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The annotation and conditions in this rule are derived from the following entries: P0ABP8 (DEOD_ECOLI)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 5 - 5 aligns to "H" in entry P0ABP8 (individually applies "Purine nucleoside; shared with dimeric partner")
    • Subsequence at position 21 - 21 aligns to "G" in entry P0ABP8 (individually applies "Phosphate; via amide nitrogen")
    • Subsequence at position 25 - 25 aligns to "R" in entry P0ABP8 (individually applies "Phosphate")
    • Subsequence at position 44 - 44 aligns to "R" in entry P0ABP8 (individually applies "Phosphate; shared with dimeric partner")
    • Subsequence at position 88 - 91 aligns to "R-[IV]-G-[TS]" in entry P0ABP8 (individually applies "Phosphate binding")
    • Subsequence at position 180 - 182 aligns to "[ED]-M-E" in entry P0ABP8 (individually applies "Purine nucleoside binding")
    • Subsequence at position 204 - 205 aligns to "[ST]-[DN]" in entry P0ABP8 (individually applies "Purine nucleoside binding")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Purine nucleoside phosphorylase DeoD-type (EC:2.4.2.1)
    Short name:
    PNP

Gene namei

  • Name:deoD

Subunit structurei

  • Homohexamer.

Sequence similaritiesi

Catalytic activityi

  • Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.
  • Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.

Regioni

  • Phosphate binding (to residues corresponding to positions 88 - 91)
  • Purine nucleoside binding (to residues corresponding to positions 180 - 182)
  • Purine nucleoside binding (to residues corresponding to positions 204 - 205)

Modified residuei

  • N6-acetyllysine (to residues corresponding to position 27)

Binding sitei

  • Purine nucleoside; shared with dimeric partner (to residues corresponding to position 5)
  • Phosphate; via amide nitrogen (to residues corresponding to position 21)
  • Phosphate (to residues corresponding to position 25)
  • Phosphate; shared with dimeric partner (to residues corresponding to position 44)

Keywordsi

GO (Gene Ontology) termsi

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