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The annotation and conditions in this rule are derived from the following entries: P0A7I7 (RIBA_ECOLI), O08315 (RIBA_HELPY)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 49 - 53 aligns to entry P0A7I7 (individually applies "GTP")
    • Subsequence at position 54 - 54 aligns to "C" in entry P0A7I7 (individually applies "Zinc; catalytic")
    • Subsequence at position 65 - 65 aligns to "C" in entry P0A7I7 (individually applies "Zinc; catalytic")
    • Subsequence at position 67 - 67 aligns to "C" in entry P0A7I7 (individually applies "Zinc; catalytic")
    • Subsequence at position 70 - 70 aligns to "Q" in entry P0A7I7 (individually applies "GTP")
    • Subsequence at position 92 - 94 aligns to "E-G-R" in entry P0A7I7 (individually applies "GTP")
    • Subsequence at position 114 - 114 aligns to "T" in entry P0A7I7 (individually applies "GTP")
    • Subsequence at position 126 - 126 aligns to "D" in entry P0A7I7 (individually applies "Proton acceptor")
    • Subsequence at position 128 - 128 aligns to "R" in entry P0A7I7 (individually applies "Nucleophile")
    • Subsequence at position 149 - 149 aligns to "[TS]" in entry P0A7I7 (individually applies "GTP")
    • Subsequence at position 154 - 154 aligns to "K" in entry P0A7I7 (individually applies "GTP")

... then these annotations are applied i

Protein namei

  • Recommended name:
    GTP cyclohydrolase-2 (EC:3.5.4.25)
    Alternative name(s):
    GTP cyclohydrolase II

Gene namei

  • Name:ribA

Cofactori

  • Zn2+Note: Binds 1 zinc ion per subunit.

Functioni

  • Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

Catalytic activityi

  • GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.

Sequence similaritiesi

Pathwayi

  • Pathwayi: riboflavin biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP. This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Subunit structurei

  • Homodimer.

Nucleotide bindingi

  • GTP (to residues corresponding to positions 49 - 53)
  • GTP (to residues corresponding to positions 92 - 94)

Active sitei

  • Proton acceptor (to residues corresponding to position 126)
  • Nucleophile (to residues corresponding to position 128)

Metal bindingi

  • Zinc; catalytic (to residues corresponding to position 54)
  • Zinc; catalytic (to residues corresponding to position 65)
  • Zinc; catalytic (to residues corresponding to position 67)

Binding sitei

  • GTP (to residues corresponding to position 70)
  • GTP (to residues corresponding to position 114)
  • GTP (to residues corresponding to position 149)
  • GTP (to residues corresponding to position 154)

Keywordsi

GO (Gene Ontology) termsi

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