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The annotation and conditions in this rule are derived from the following entries: P07649 (TRUA_ECOLI)

If a protein meets these conditions... i

Common conditions

Special conditions

  • Subsequence at position 58 - 58 aligns to "R" in entry P07649 (applies "Interaction with tRNA. Important for base-flipping") Subsequence at position 78 - 78 aligns to "R" in entry P07649 (applies "Interaction with tRNA") Subsequence at position 107 - 111 aligns to "F-H-A-R-F" in entry P07649 (applies "RNA binding") Subsequence at position 110 - 110 aligns to "R" in entry P07649 (applies "Interaction with tRNA") Subsequence at position 126 - 126 aligns to "R" in entry P07649 (applies "Interaction with tRNA") Subsequence at position 139 - 139 aligns to "F" in entry P07649 (applies "Interaction with tRNA") Subsequence at position 168 - 172 aligns to "Q-C-Q-S-R" in entry P07649 (applies "Interaction with tRNA")
    • Subsequence at position 60 - 60 aligns to "D" in entry P07649 (individually applies "Nucleophile")
    • Subsequence at position 118 - 118 aligns to "Y" in entry P07649 (individually applies "Substrate")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

  • Recommended name:
    tRNA pseudouridine synthase A (EC:5.4.99.12)
    Alternative name(s):
    tRNA pseudouridylate synthase I
    tRNA pseudouridine(38-40) synthase
    tRNA-uridine isomerase I

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:truA

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This section describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Homodimer.

<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Substrate (to residues corresponding to position 118)

<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni

  • RNA binding (to residues corresponding to positions 107 - 111)
  • Interaction with tRNA (to residues corresponding to positions 168 - 172)

<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Nucleophile (to residues corresponding to position 60)

<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei

  • Interaction with tRNA. Important for base-flipping (to residues corresponding to position 58)
  • Interaction with tRNA (to residues corresponding to position 78)
  • Interaction with tRNA (to residues corresponding to position 110)
  • Interaction with tRNA (to residues corresponding to position 126)
  • Interaction with tRNA (to residues corresponding to position 139)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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