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The annotation and conditions in this rule are derived from the following entries: O87703 (DNLJ_GEOSE), P15042 (DNLJ_ECOLI), Q9AIU7 (DNLJ_STAAU), P9WNV1 (DNLJ_MYCTU), Q837V6 (DNLJ_ENTFA), Q9ZHI0 (DNLJ_THEFI)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 39 - 43 aligns to "D-x-x-[YF]-D" in entry Q837V6 (individually applies "NAD")
    • Subsequence at position 175 - 175 aligns to "E" in entry Q837V6 (individually applies "NAD")
    • Subsequence at position 291 - 291 aligns to "K" in entry Q837V6 (individually applies "NAD")
    • Subsequence at position 412 - 412 aligns to "C" in entry Q837V6 (individually applies "Zinc")
    • Subsequence at position 120 - 120 aligns to "K" in entry Q837V6 (individually applies "N6-AMP-lysine intermediate")
    • Subsequence at position 141 - 141 aligns to "R" in entry Q837V6 (individually applies "NAD")
    • Subsequence at position 409 - 409 aligns to "C" in entry Q837V6 (individually applies "Zinc")
    • Subsequence at position 427 - 427 aligns to "C" in entry Q837V6 (individually applies "Zinc")
    • Subsequence at position 88 - 89 aligns to "S-x" in entry Q837V6 (individually applies "NAD")
    • Subsequence at position 315 - 315 aligns to "K" in entry Q837V6 (individually applies "NAD")
    • Subsequence at position 432 - 432 aligns to "C" in entry Q837V6 (individually applies "Zinc")
    • Subsequence at position 118 - 118 aligns to "[ED]" in entry Q837V6 (individually applies "NAD")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:ligA

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

    • NAD(+) + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + beta-nicotinamide D-nucleotide. EC:6.5.1.2

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • N6-AMP-lysine intermediate (to residues corresponding to position 120)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • NAD (to residues corresponding to position 175)
  • NAD (to residues corresponding to position 291)
  • NAD (to residues corresponding to position 141)
  • NAD (to residues corresponding to position 315)
  • NAD (to residues corresponding to position 118)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Zinc (to residues corresponding to position 412)
  • Zinc (to residues corresponding to position 409)
  • Zinc (to residues corresponding to position 427)
  • Zinc (to residues corresponding to position 432)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi

  • NAD (to residues corresponding to positions 39 - 43)
  • NAD (to residues corresponding to positions 88 - 89)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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