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The annotation and conditions in this rule are derived from the following entries: P25552 (GPPA_ECOLI)

If a protein meets these conditions... i

Common conditions

... then these annotations are applied i

Protein namei

  • Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolase

Gene namei

  • Name:gppA


  • Pathwayi: ppGpp biosynthesis

    This protein is involved in step 2 of the subpathway that synthesizes ppGpp from GTP. This subpathway is part of the pathway ppGpp biosynthesis, which is itself part of Purine metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes ppGpp from GTP, the pathway ppGpp biosynthesis and in Purine metabolism.


  • Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.

Catalytic activityi

  • Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.

Sequence similaritiesi


GO (Gene Ontology) termsi

  • GO:0008894 guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity
  • GO:0015974 guanosine pentaphosphate catabolic process

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