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The annotation and conditions in this rule are derived from the following entries: P24009 (COXX2_BACSU), O31652 (COXX1_BACSU), P0AEA5 (CYOE_ECOLI), Q3J5F9 (COXX_RHOS4)

If a protein meets these conditions... i

Common conditions

Special conditions

    • proteome property = Membrane=2
    • proteome property = Membrane=1
    • proteome property ≠ Membrane=*
    • taxon = Shigella, Salmonella, Escherichia
    • Subsequence at position 57 - 78 aligns to entry P0AEA5 (individually applies "Cytoplasmic")
    • Subsequence at position 98 - 107 aligns to entry P0AEA5 (individually applies "Periplasmic")
    • Subsequence at position 127 - 197 aligns to entry P0AEA5 (individually applies "Cytoplasmic")
    • Subsequence at position @NTER@ - 9 aligns to entry P0AEA5 (individually applies "Cytoplasmic")
    • Subsequence at position 288 - @CTER@ aligns to entry P0AEA5 (individually applies "Periplasmic")
    • Subsequence at position 248 - 268 aligns to entry P0AEA5 (individually applies "Cytoplasmic")
    • Subsequence at position 217 - 228 aligns to entry P0AEA5 (individually applies "Periplasmic")
    • Subsequence at position 29 - 37 aligns to entry P0AEA5 (individually applies "Periplasmic")
    • Predicted transmembrane

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

  • Recommended name:
    Protoheme IX farnesyltransferase (EC:2.5.1.141)
    Alternative name(s):
    Heme B farnesyltransferase
    Heme O synthase

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi

  • Name:cyoE
  • Name:ctaB

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Interacts with CtaA.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

  • Pathwayi: heme O biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes heme O from protoheme. This subpathway is part of the pathway heme O biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes heme O from protoheme, the pathway heme O biosynthesis and in Porphyrin-containing compound metabolism.

<p>This subsection of the ‘Function’ section describes relevant information that doesn’t fall into the scope of any other subsections, but is thought to be valuable enough to be cited in UniProtKB.<p><a href='/help/miscellaneous' target='_top'>More...</a></p>Miscellaneousi

  • Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei

  • Helical (to residues corresponding to positions @FROM@i - @TO@i)

<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini

  • Cytoplasmic (to residues corresponding to positions 57 - 78)
  • Periplasmic (to residues corresponding to positions 98 - 107)
  • Cytoplasmic (to residues corresponding to positions 127 - 197)
  • Cytoplasmic (to residues corresponding to positions @NTER@i - 9)
  • Periplasmic (to residues corresponding to positions 288 - @CTER@i)
  • Cytoplasmic (to residues corresponding to positions 248 - 268)
  • Periplasmic (to residues corresponding to positions 217 - 228)
  • Periplasmic (to residues corresponding to positions 29 - 37)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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